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Alert: Important Update for US patients - Upcoming U.S. Government changes. Click to read more
Xeljanz (tofacitinib) is a prescription Janus kinase (JAK) inhibitor used to treat certain inflammatory and immune-mediated conditions. It is approved for adults with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and moderately to severely active ulcerative colitis. It is also approved for certain pediatric patients with PsA or Polyarticular-course juvenile idiopathic arthritis (pcJIA).
Because Xeljanz is available in different strengths and formulations, treatment and cost can vary depending on the condition, prescribed dose, insurance coverage, pharmacy, and generic availability.
Xeljanz contains tofacitinib and works by inhibiting JAK enzymes involved in immune system signaling. It may be prescribed for:
For Adult indication, when they have had an inadequate response or intolerance to one or more TNF blockers, as specified in the prescribing information. The appropriate dose depends on the condition being treated, individual factors, age, kidney and liver function, and other medicines.
The Xeljanz cost without insurance can vary based on:
The price displayed online may not be the final amount you will have to pay. Start with the savings option that matches your situation.
Check whether you qualify for a manufacturer co-pay or savings program. These programs may help eligible commercially insured patients reduce their out-of-pocket costs. Eligibility rules apply, so check the current terms directly through the manufacturer or an authorized healthcare resource.
Without insurance, patients may need to pay full pharmacy price unless they qualify for another savings option. Possible options include:
Manufacturer co-pay programs may have eligibility restrictions for people enrolled in government-sponsored plans. Check your plan’s formulary and cost-sharing requirements and review any patient-assistance programs or charitable options that may be available to you.
Yes. FDA records include generic tofacitinib products in the U.S. However, availability can vary by formulation, manufacturer, pharmacy, and market.
Xeljanz is available as immediate-release tablets, Xeljanz XR extended-release tablets, and oral solution. When comparing a generic product with Xeljanz, verify the active ingredient, strength, formulation, manufacturer, and regulatory approval.
The term “generic Xeljanz” does not automatically mean it is an FDA-approved generic equivalent. Always verify its regulatory status and manufacturer before purchasing. You can verify approved generic products through the FDA’s Drugs@FDA database.
The appropriate Xeljanz dose depends on the condition being treated, formulation, age, kidney or liver function, and other medicines being taken. For adults with rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis, commonly listed regimens include:
Dosing for ulcerative colitis differs between induction and maintenance regimens. Xeljanz is available as 5 mg and 10 mg tablets, 11 mg and 22 mg extended-release tablets, and a 1 mg/mL oral solution.
Xeljanz XR is not interchangeable with regular Xeljanz tablets or oral solution, so any change in formulation should be made by your healthcare professional. Do not change your Xeljanz dose or switch formulations on your own. Dose adjustments based on kidney or liver function or certain drug interactions.
Common side effects reported with Xeljanz include:
More serious risks include:
which are included in the medicine's boxed warning.
Xeljanz treatment may also require monitoring of blood counts, liver enzymes, and lipid levels.
Xeljanz can interact with medicines that affect its metabolism. Some combinations, including certain biologic DMARDs and potent immunosuppressants such as azathioprine or cyclosporine, are not recommended.
Xeljanz and Rinvoq are both oral JAK inhibitors, but they contain different active ingredients. Xeljanz contains tofacitinib, while Rinvoq contains Upadacitinib. Their FDA-approved uses overlap for some conditions but are not identical.
| Factor | Xeljanz | Rinvoq |
|---|---|---|
| Active ingredient | Tofacitinib | Upadacitinib |
| Drug class | JAK inhibitor | JAK inhibitor |
| Administration | Oral | Oral |
| Formulations | Tablets, XR tablets, oral solution | Extended-release tablets |
| Approved uses | Several inflammatory conditions | Several inflammatory conditions |
| Dosing | Varies by condition; some adult indications use twice-daily dosing or once-daily XR dosing | Many adult indications use once-daily dosing, with the dose depending on the condition |
| Major safety considerations | Serious infections, malignancy, MACE, thrombosis | Serious infections, malignancy, MACE, thrombosis |
| Cost and access | Varies by coverage and availability | Varies by coverage and availability |
Xeljanz is a prescription medicine. Before ordering online, use these three golden rules:
Be cautious of websites that sell prescription medication without proper requirements, hide their identity, offer prices that seem unusually low, and make guarantees or claims of "risk-free" treatment.
Before purchasing Xeljanz online:
The same medicine may have different regulatory approvals, formulations, or brand names in different markets. Do not assume that a product listed under a different name is automatically equivalent.
Always verify the:
with a licensed pharmacist before purchasing.
Xeljanz costs can vary depending on insurance benefits; explore legitimate assistance programs, dosage, pharmacy, and ask your pharmacist about approved generic tofacitinib options.
Most importantly, don't let a tempting online price lead you to an unverified seller. Your prescription, a licensed pharmacy, and medication safety should always come first.
You shouldn't have to sacrifice your health because of high prices. To check our current stock, compare Xeljanz cost, and securely upload your prescription today.
Follow the instructions provided with your prescription and contact your pharmacist or prescribing healthcare professional if you are unsure what to do. Do not double your next dose unless your healthcare professional specifically tells you to.
Generic tofacitinib may cost less than brand-name Xeljanz, but prices vary by formulation, manufacturer, pharmacy, location, insurance coverage, and availability.
Seek medical attention for symptoms such as persistent fever, chills, severe weakness, shortness of breath, or a worsening cough. Xeljanz can increase the risk of serious infections, including tuberculosis and other bacterial, viral, and fungal infections. Do not ignore rapidly worsening symptoms.
Some over-the-counter pain relievers may be used with Xeljanz, but this depends on your health and other medicines. Tell your doctor or pharmacist if you take ibuprofen, naproxen, aspirin, or acetaminophen. They can advise you on the best option.
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