ZANIDIP (LERCANIDIPINE)

Zanidip is a brand name for the generic medication Lercanidipine Hydrochloride. It is a prescription, FDA-approved drug for the treatment of hypertension in adults.

Zanidip contains Lercanidipine Hydrochloride as the active ingredient and other inactive excipients including microcrystalline cellulose, lactose monohydrate, povidone, sodium starch glycollate type A, magnesium stearate, purified talc, Hypromellose, macrogol 6000, and titanium dioxide. Lercanidipine is an odorless, microcrystalline, citrine powder, insoluble in water and chemically designated as 3,5-pyridine dicarboxylic acid, 1,4-dihydro-2, 6-dimethyl-4-(3-nitrophenyl)-2-[(3,3-diphenylpropyl) methylamino]-1,1-dimethylethyl methyl ester hydrochloride.

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Zanidip belongs to the pharmacological class of Calcium Channel Blockers. Calcium channel blockers are the class of medications that come under dihydropyridine derivatives. Lercanidipine is a calcium channel antagonist. It selectively inhibits the transmembrane calcium influx into vascular and cardiac smooth muscles. It has a direct effect of relaxing the vascular smooth muscles which reduces peripheral resistance and further the blood pressure. The vasodilation effect has a gradual onset, meaning the medication rarely causes acute hypotension with reflex tachycardia in hypertensive patients.

Zanidip tablets come in two strengths: 10mg and 20mg, in a pack of 28 tablets.

• 10 mg Zanidip tablets are round, scored, film-coated tablets. They are yellow because of their ingredient yellow iron oxide.
• 20 mg Zanidip tablets are circular, biconvex, film-coated tablets. They are pink in color because of their ingredient red iron oxide.

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Zanidip medication's purpose is to treat mild to moderate essential hypertension. Zanidip is given to lower blood pressure. It relaxes and widens the blood vessels in the body and brings back the blood pressure to normal by decreasing resistance to blood flow. Suppose Zanidip is not taken regularly or hypertension is left untreated for long. In that case, the condition can worsen and lead to other health complications such as stroke, heart disease, and kidney failure.

• The suggested dosage of Zanidip is 10 mg once daily, at least 15 minutes before having a meal. The best effect of the medication is when Zanidip is taken at the same time daily.
• Gradually titrate the Zanidip dose as it takes about 2 weeks for the maximal anti-hypertensive effect to be apparent.
• The maximum recommended daily dosage is 20 mg daily.

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• Zanidip tablets are meant for oral administration.
• Swallow the Zanidip tablet with a glass of water. Do not crush, chew, cut, or dissolve the medication.
• The oral route allows the medicine to be directly absorbed into the blood and reach the target organs for the best and most effective outcomes.

The mild side effects include:

• Palpitations
• Flushing
• Swollen ankles, feet, or lower legs.
• Fainting or Dizziness.
• Tiredness or Sleepiness.
• Headache
• Gastrointestinal disturbances such as nausea, heartburn, diarrhea, or epigastric pain.

The serious side effects include:

• Increased heartbeat.
• Angina (tightness or pain in the chest).
• Signs of allergic reaction such as itching, rash, or hives in the skin.

Some people may experience other side effects that are not on this list. If so, they should report them to their doctor.

Some of the drugs known to interact with Zanidip include:

• Ciclosporin
• Astemizole
• Antibiotics such as Clarithromycin, Troleandomycin, and Erythromycin.
• Cimetidine (more than 800 mg taken daily).
• Fluoxetine
• Antivirals such as Ritonavir.
• Antifungal medications such as Itraconazole and Ketoconazole.
• Propranolol, Metoprolol
• Rifampicin
• Terfenadine
• Some anti-depression medications.
• Some medications to treat epilepsy such as Phenobarbital, Phenytoin, and Carbamazepine.
• Some medications to treat an enlarged prostate and improve urinary symptom.
• Corticosteroids are used to treat inflammation, autoimmune conditions, and allergies.

Other drugs can interact with Zanidip and are not mentioned here. Therefore, you should inform your doctor about your current intake of drugs to ensure that they do not affect Zanidip.

Zanidip is not safe for use by:

• Anyone having known hypersensitivity to the active ingredient or any content of Zanidip tablet or are allergic to any food, preservatives or dyes, or other medications.
• Patients having an obstruction in the left ventricular outflow tract.
• Patients having untreated congestive heart failure, a recent myocardial infarction, or unstable angina pectoris.
• Patients suffering from severe hepatic impairment or severe renal impairment, including dialysis patients.
• Patients suffering from left ventricular dysfunction, galactose intolerance, sick sinus syndrome, and ischaemic heart disease.
• Women who are pregnant or intend to get pregnant.
• Breastfeeding women.
• Children under the age of 18 years.

When taking Zanidip, it is important to watch for the following:

• Before starting the course of Zanidip, inform the doctor of any existing allergies or medical conditions, current intake of medications/supplements, whether pregnant or breastfeeding and other significant health-related facts.
• Avoid taking Zanidip tablets with grapefruit or grapefruit juice as there can be unwanted interactions.
• Keep a regular check of your blood pressure and take tablets exactly as per doctor’s prescription.
• Do not make up for missed doses by doubling the dose.
• Be careful while driving or using any machines until you know the effect of Zanidip on you.
• Limit or stop alcohol intake while taking Zanidip to keep blood pressure under control.
• Do not take Zanidip if it is out of date, the tablets show signs of deterioration, or the package is torn.

• Store Zanidip tablets in their blistered pack at room temperature, preferably 15-30°C.
• Keep away from light, moisture, heat, and small children.
• Keep away from pets.

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