VYTORIN (EZETIMIBE/SIMVASTATIN)

Vytorin is a brand name for a combination of generic medications containing Ezetimibe and Simvastatin. It is a prescription medication that got FDA approval in 2004 for lowering the bad cholesterol (low-density lipoprotein) and triglyceride levels in the blood while increasing the good cholesterol (high-density lipoprotein). The drug is taken together with a low-fat diet and other treatments that help in lowering total cholesterol levels in the blood.

Vytorin tablet contains Ezetimibe and Simvastatin as the active ingredients along with the following inactive ingredients: magnesium stearate NF, butylated hydroxyanisole NF, lactose monohydrate NF, propyl gallate NF, croscarmellose sodium NF, microcrystalline cellulose NF, Hypromellose USP, and citric acid monohydrate USP. Are you searching for Vytorin at a discounted price in pharmacy stores? Buy Vytorin Online with CanadaPharmacyPro and get it at the best price.

Vytorin belongs to the pharmacological class of Antihyperlipidemic combinations. It has ezetimibe which is a selective inhibitor of intestinal cholesterol and related absorption of phytosterol and simvastatin which is an HMG-CoA reductase inhibitor (statin). HMG-COA reductase inhibitors are a class of medications that work to avoid the building of cholesterol from dietary fat.

Together, ezetimibe and simvastatin reduce total cholesterol, triglycerides, and low-density lipoprotein concentrations in the blood and increase high-density lipoprotein in the blood. They are used in adjunct with proper diet and exercise.

Vytorin is a white to off-white capsule-shaped tablet available in four different strengths:

• 10/10: This strength tablet contains 10mg ezetimibe and 10mg simvastatin. It has the code “311” on one side.
• 10/20: This strength tablet contains 10mg ezetimibe and 20mg simvastatin. It has the code “312” on one side.
• 10/40: This strength tablet contains 10mg ezetimibe and 40mg simvastatin. It has the code “313” on one side.
• 10/80: This strength tablet contains 10mg ezetimibe and 40mg simvastatin. It has the code “315” on one side.

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Vytorin is given by a doctor in adjunct to a low-fat diet to alter lipid levels in the blood. This medicine is recommended to patients when they are not able to respond to a saturated fat cholesterol diet restriction and other non-pharmacological processes.

This drug is taken for the following indications:

• Primary or mixed hyperlipidemia: Vytorin can help reduce elevated levels of low-density lipoprotein, total cholesterol, triglycerides, and apoB while increasing the low levels of high-density lipoprotein. Thus, it is beneficial for patients suffering from a liver disorder- the primary (heterozygous familial and non-familial) or mixed hyperlipidemia.
• Homozygous Familial Hypercholesterolemia: Vytorin can help treat this rarely-occurring life-threatening condition that is characterized by elevated levels of circulating low-density lipoprotein cholesterol and total cholesterol as well as accelerated, premature atherosclerotic cardiovascular disease.

• The usual suggested dosage range is 10/10mg per day to 10/40mg per day. The drug is meant to be taken daily in the evening, a single dose with or without food.
• The usual initial recommended dosage is 10/10mg per day or 10/20mg per day.
• The dosage can be adjusted, if needed, after taking a lipid profile test following 2 or more weeks of taking the medication.

The suggested dosage for patients with homozygous familial hypercholesterolemia is 10/40mg daily once in the evening.

Vytorin is available in the form of tablets meant for oral administration. It is taken once daily with or without food. Follow the dosage instructions provided by the doctor. Do not crush, chew, or break the tablets, and swallow them as a whole with water. The oral tablet allows easy administration and absorption into the body. This also makes it convenient for patients to take the medication. This form also helps in managing cholesterol levels over time.

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Commonly reported unwanted effects of taking Vytorin are:

• Headache
• Muscle pain
• Diarrhea
• Unusual liver function tests.
• Cold symptoms such as sneezing, stuffy nose, and sore throat.

Some of the serious side effects of taking Vytorin include:

• Myopathy (Muscle pain, Weakness, and Tenderness).
• Muscle painLiver problems (Jaundice)
• Signs of an increase in blood sugar levels.
• Upper stomach ache and loss of appetite.
• Sleep problems
• Numbness or tingling sensation.
• Memory problems, depression.
• Dizziness
• Nausea
• Vomiting
• Fever

Here is a list of some of the drugs known to interact with Vytorin:

• Blood thinners such as warfarin, jantoven, or Coumadin.
• Heart or blood pressure medication.
• Danazol, cyclosporine, or gemfibrozil.
• Antibiotics like erythromycin and clarithromycin.
• Antifungals like itraconazole and ketoconazole.
• HIV protease inhibitors such as tipranavir, indinavir, ritonavir, nelfinavir, saquinavir, or atazanavir.
• Antidepressants like nefazodone.
• Hepatitis C viruses protease inhibitors such as telaprevir or boceprevir.

Intake of Vytorin is unsafe for:

• Anyone under 10 years old.
• Girls who have not started having menses.
• Patients suffering from liver disease or those who are diagnosed with abnormal liver functioning.
• Patients who have kidney or thyroid problems.
• Anyone who is allergic to any of the components of Vytorin.
• Pregnant women
• Nursing mothers

Take note of the following precautions while taking Vytorin:

• Avoid drug/disease interactions with Vytorin by sharing information about your current intake of drugs, and illnesses (if any) with your doctor.
• Avoid sudden discontinuation of intake of Vytorin tablets, their overdose, or skipping of the dose.
• Inform the doctor beforehand if pregnant, planning childbearing, or breastfeeding.
• Avoid alcohol intake. Alcohol can raise triglyceride levels and increase the risk of liver damage.
• Avoid consumption of grapefruit-containing products as grapefruit may interact with Vytorin.
• Do not eat fatty foods or else you cannot benefit from Vytorin.
• Do not follow a sedentary lifestyle or have bad lifestyle habits.

• Store Vytorin tablets at controlled room temperature, preferably at 20-25℃.
• Keep the supply bottle tightly closed away from light, heat, and moisture, and out of reach of small children.

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