TRICOR (FENOFIBRATE)

Tricor is a brand name for a generic medication called Fenofibrate. It is a prescription drug that got FDA approval in 2004 for regulating blood cholesterol levels. It helps in the reduction of bad cholesterol and high levels of fatty acids (triglycerides) in the blood while raising the levels of good cholesterol.

FDA gave usage clearance for Tricor only when a less fatty diet and regular exercise alone were not enough to manage cholesterol. Adults can take Tricor along with a doctor-recommended healthy diet to lower the severely elevated triglyceride levels in the blood.

Tricor tablets contain Fenofibrate as its active ingredient and the following inactive ingredients: polyvinyl alcohol, colloidal silicon dioxide, microcrystalline cellulose, crospovidone, lecithin, lactose monohydrate, povidone, sodium stearyl fumarate, sodium lauryl sulfate, talc, xanthan gum, and titanium dioxide. Fenofibrate is a lipid regulating agent, a white solid, chemically designated as 2-[4-(4-chlorobenzene) phenoxy]-2-methyl-propanoic acid, 1-methyl ethyl ester.

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Tricor belongs to the pharmacological class: Fibric Acid Agents/ Derivatives. Fibric Acid Agents/ Derivatives or Fibrates are broad-spectrum lipid regulating/lowering agents that can treat hypercholesterolemia and hypertriglyceridemia. Their main action is to remove triglycerides from the blood swiftly.

But they even tend to suppress the production of very low-density lipoprotein (bad cholesterol) by the liver and moderately increase high-density lipoprotein (good cholesterol) in the blood. They do not work to lower the level of low-density lipoprotein.

Fibrates appear to activate PPAR (peroxisome proliferator-activated receptor)-alpha protein. This protein further activates lipoprotein lipase enzyme and ultimately helps regulate lipids within the body.

Tricor tablets come in the following two strengths:

• 48mg: These strength tablets are yellow and imprinted with code identification letters “FI” and “a” logo. Their yellow color is because of the following inactive ingredients: D&C Yellow No. 10, FD&C Yellow No. 6, and FD&C Blue No. 2.
• 145mg: These strength tablets are white and imprinted with code identification letters “FO” and “a” logo.

Tricor tablets are given by doctors in adjunct to proper diet and exercise regime for the following indications:

• Primary hypercholesterolemia or Mixed Dyslipidemia: Primary hypercholesterolemia is a lipid disorder that manifests as markedly high levels of low-density lipoprotein and apoB. Mixed dyslipidemia is a condition wherein there are raised triglyceride and LDL cholesterol levels accompanied by low HDL cholesterol levels. Tricor can help reduce total cholesterol, elevated low-density lipoprotein, high levels of triglycerides, and Apo-B and elevate the low levels of high-density lipoprotein, thereby treating both of these conditions.
• Severe hypertriglyceridemia: This condition is characterized by the presence of too many fatty acids in the blood. Tricor can help reduce the high amounts of triglycerides in the blood, thereby reducing the risk of atherosclerosis or other heart disease.

• The initial dose in adults with primary hypercholesterolemia is 145mg once/ daily.
• The suggested initial dose of Tricor tablet for patients suffering from severe hypertriglyceridemia is 48 to 145mg once daily.
• The maximum recommended dose is 145mg per day.
• Geriatric patients should select the dose based on their renal function.
• The recommended initial dose for kidney patients is 48mg once daily.

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Tricor is available as a tablet meant for oral administration. Take tablets with or without food while following a proper diet plan, exercise regime, and intake of other medications. When taken orally it is absorbed into the bloodstream through the digestive system. Oral intake allows the medication to be metabolized and distributed throughout the body, enabling it to reach its targets and provide desired therapeutic effects.

The common side effects of taking Tricor include:

• Nausea
• Vomiting
• Stomach or abdominal pain.
• Backache
• Headache
• Dark urine/
• Skin rash/
• Stuffy or runny nose.
• Itching

Some of the adverse effects of taking Tricor include:

• Severe skin reaction or allergic reaction.
• Sharp pain in the stomach that radiates to the shoulder blade or back.
• Skin/eyes yellowing (Jaundice).
• Appetite loss.
• Chest pain, rapid breathing, wheezing, sudden cough, coughing up blood.
• Severe liver injury.
• Inflammation of the gallbladder or the pancreas.
• Warmth, swelling, or redness in the leg or arm.

Here are some of the drugs known to show unwanted interactions with Tricor:

• Blood thinners.
• Drugs that prevent rejection of organ transplant.
• Antiviral medications.
• Medications to treat a bowel disorder.
• Pain or arthritis medicine.
• Chemotherapy drugs.
• Injected antibiotics.
• Other cholesterol-lowering drugs.

Intake of Tricor tablets is unsafe for:

• Pregnant or breastfeeding women.
• Anyone aged under 18 years.
• People with a history of pancreatitis should avoid taking this medicine.
• It should not be taken by people with untreated thyroid disorders.
• The medicine must be taken carefully in people who taking antibiotics, HIV medications, and certain heart medications.
• Anyone having known hypersensitivity or allergy to any contents of Tricor tablets.
• Patients suffering from illnesses like liver disease, severe kidney disease (including dialysis patients), or gallbladder disease.

Take note of the following precautions while taking Tricor:

• Avoid drug/disease interactions with Tricor by sharing information about your current intake of drugs, and illnesses (if any) with your doctor.
• Avoid sudden discontinuation of intake of Tricor tablets, overdose, or skipping of dose.
• Inform the doctor beforehand if pregnant, planning childbearing, or breastfeeding.
• Avoid alcohol intake. Alcohol can raise triglyceride levels and increase the risk of liver damage.
• Do not eat fatty foods or Tricor won’t be very effective.
• Do not follow a sedentary lifestyle or have bad lifestyle habits.
• Avoid grapefruit and its juice while taking this medication.
• The medicine can cause muscle-related side effects. If one experiences muscle pain, tenderness, or weakness. Consult a doctor immediately.
• The medication can affect liver enzymes. It is advised to undergo liver function tests while taking this medication.

• Store Tricor supplies bottles tightly closed at controlled room temperature, preferably at 20-25℃.
• Keep the supply bottles away from heat and moisture and out of reach of small children.
• The tablets may get spoilt or their efficacy may become low below 15℃ and above 35℃.

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