TAPAZOLE (METHIMAZOLE)

Tapazole is a brand name given by AAI Pharma for the anti-thyroid generic medication Methimazole. This prescription drug got FDA approval in 1950 for use in the treatment of overactive thyroid, the condition medically known as hyperthyroidism. The doctors even prescribe it for intake before thyroid surgery or radioactive iodine treatment.

Tapazole tablets contain Methimazole as its active ingredient and the following inactive ingredients: pregelatinized starch, lactose monohydrate, talc, starch (corn), and magnesium stearate. Methimazole is a white-crystalline, freely water-soluble substance, a 5-membered ring, chemically designated as 1-methylimidazole-2 thiol.

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Tapozole belongs to the pharmacological class of antithyroid agents. Antithyroid agents are a class of medications that help treat hyperthyroidism by preventing or suppressing the biosynthesis of thyroid hormones by the thyroid gland or reducing their thyroid activity.

Tapozole tablets come in two strengths:

• 5 mg: This strength tablet is round, white to off-white colored, with one side scoring and the other side debossing of “J 94”.
• 10 mg: This strength tablet is round, white to off-white colored, with one side scoring and the other side debossing of “J 95”.

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Tapazole tablets are given by doctors for the following indications:

• Grave’s disease with hyperthyroidism or toxic multinodular goiter where surgery or radioactive iodine therapy is an inappropriate treatment option. Grave’s disease is an immune system disorder wherein there is excess production of thyroid hormones.
• Overactive bladder caused by hyperthyroidism. Hyperthyroidism is a condition wherein the thyroid gland produces excess thyroid hormones than required by the body. The symptoms of an overactive bladder are fast heart rate, weight loss, sleep issues, muscle weakness, nervousness/high irritability, tremors, eye irritations, heat sensitivity, and infrequent menses.
• Preparation for intervention of thyroid gland. Anyone with symptoms of hyperthyroidism needs to prepare their thyroid gland before going for radioactive iodine therapy or thyroidectomy (excision of the thyroid gland). This is possible with Tapazole tablets.

For adults, the initial daily recommended dosage is 15 mg for mild hyperthyroidism; 30 to 40 mg in case of moderately severe hyperthyroidism; and 60 mg for severe hyperthyroidism. The suggested maintenance dosage is 5 to 15 mg daily.

For pediatric patients, the initial daily recommended dosage is 0.4 mg per kg of body weight of the child. The suggested maintenance dosage is approximately half of the prescribed initial daily dosage.

The total daily dosage for both adults and pediatric patients is given usually in 3 divided doses at a gap of approximately 8 hours.

Tapazole is available in the form of tablets for oral administration. Take the tablet either before or after meals at regular intervals. Swallow the tablets with enough water. It is important to maintain the required amount of Tapazole in the body at all times.

Commonly reported side effects of taking Tapazole include:

• Upset Stomach.
• Nausea
• Vomiting
• Dizziness
• Drowsiness
• Mild skin rash or itchy skin.
• Skin discoloration.
• Headache
• Swelling
• Hair loss
• Aching muscles or joints.
• Nerve Pain.
• Numbness or Tingling sensation.
• Reduced sense of taste.

Serious side effects of Tapazole are:

• Swollen glands in the jaw or neck.
• Signs of infection such as sudden weakness or ill feeling, painful mouth sores, easy bruising, pale skin, fever, sore throat, pain when swallowing, unusual bleeding, and cold or flu symptoms.
• Symptoms of liver problems such as jaundice, clay-colored stools, tiredness, itching, appetite loss, and nausea.

Some of the drugs known to interact with Tapazole include:

• Blood thinning medications such as Warfarin, Jantoven, and Coumadin.
• Digoxin
• Theophylline
• Digitalis Glycosides
• Theophylline
• Lithium
• Cyclosporine
• Iodine-containing contrast agents.
• Sulfonamides
• Amiodarone
• Rifampin
• Beta-blockers such as propranolol, sotalol, labetalol, nadolol, metoprolol, propranolol, and others.

Tapazole is not safe for intake by:

• Anyone having known hypersensitivity to any of the contents of Tapazole tablets.
• Pregnant women.
• Breastfeeding mothers.
• Patients who have blood cell disorder or a liver disease.
• Patients with weak immune system.
• Small children.

The patients should follow the doctor’s instructions on how to take the medicine. It is important to:

• Stay away from sick people and tell the doctor if you develop any signs of infection.
• Inform the doctor beforehand about the current intake of medications and supplements and if having any illnesses or allergies.
• Tell the doctor if you intend to get pregnant or nurse the child while taking this medication. Avoid conceiving a child or breastfeeding during the treatment course with Tapazole.
• Avoid doubling or skipping doses. A missed dose must be skipped if it's almost the time of the next dose and taken on the usual dose timing.
• Do not change the dosage or stop the intake of Tapazole without first consulting the doctor.
• Take Tapazole after meals or with milk, as it can upset the stomach.
• Regularly visit a doctor to check for the working of the medicine and to see for any wanted effects.

• Store Tapazole tablets at room temperature away from heat, moisture, and direct light.
• Keep away from small children. Avoid freezing the tablets.

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