TAMBOCOR (FLECAINIDE)

Tambocor is a brand name for a generic anti-arrhythmic drug called flecainide. This prescription medicine got FDA approval in 1985 for distribution by iNova Pharmaceuticals to prevent serious disorders related to heart rhythm. It is usually given by the doctor to prevent irregular heartbeat in patients suffering from chronic ventricular tachycardia, paroxysmal supraventricular tachycardia, and atrial fibrillation.

Tambocor tablets have Flecainide Acetate as the active ingredient and even contain non-active ingredients like hydrogenated vegetable oil, croscarmellose sodium, microcrystalline cellulose, magnesium stearate, and starch. Flecainide acetate is a white crystalline substance chemically designated as benzamide, N-(2-piperidinylmethyl)-2,5-bis (2,2,2-trifluoroethoxy)-monoacetate.

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Tambocor belongs to the pharmacological class: Group 1 Antidysrhythmics. Group 1 Antidysrhythmics or Antiarrhythmics are the class of medications, the sodium channel blockers, that help prevent abnormal cardiac rhythms by blocking the fast sodium channels present in the cardiac muscles and thereby slowing electrical conduction in the heart. The medication has the strongest effect on the phase 0 of depolarization. It prolongs the PR interval and widens the QRS complex.

Tambocor tablets come in three strengths:

• 50 mg: This strength tablet is white and round with embossing of 3M on one side and TR 50 on the other.
• 100 mg: This strength tablet is a white and round scored tablet with 3M embossed on one side and TR 50 on the other.
• 150 mg: This strength tablet is a white and oval scored tablet with 3M embossed on one side and TR150 on the other.

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Tambocor tablets are given by doctors for the following indications:

• Supraventricular Arrhythmias: It is a common type of arrhythmia wherein the heart beats suddenly faster than usual or erratically. This begins above the lower two heart chambers-the ventricles. Tambocor is given in cases of non-structural heart diseases- the paroxysmal supraventricular tachycardias including atrioventricular reentrant tachycardia, atrioventricular nodal reentrant tachycardia, or other kinds of supraventricular tachycardias of unspecified mechanism accompanied by disabling symptoms. It is even given to prevent paroxysmal atrial fibrillation/flutter associated with disabling symptoms.
• Life-threatening ventricular arrhythmias: It is the fast heartbeat arising from the lower heart chambers called ventricles. Tambocor is given to prevent sustained ventricular tachycardia.

For patients suffering from paroxysmal supraventricular tachycardias and paroxysmal atrial fibrillation/flutter, the initial recommended dose is 50 mg every 12 hours.

For patients suffering from life-threatening sustained ventricular tachycardia, Tambocor is given initially in a hospital setting with rhythm monitoring. The initial recommended dose is 100 mg every 12 hours.

The dosage in either case can be increased by 50 mg every 4 days until the achievement of efficacy of the medication. Typically, 150 mg every 12 hours is usually the patient's need. The maximum recommended dose is 400 mg/day.

Tambocor is available as a tablet for oral administration. Take the tablet either before or after meals. Swallow the tablets with enough water. One must also follow the doctor's advice before taking this medicine.

Commonly reported side effects of taking Tambocor include:

• Dizziness
• Nausea
• Headache
• Vision problems.
• Weakness or Tiredness.

Serious side effects include:

• Signs of an allergic reaction.
• Swelling.
• Rapid weight gain.
• Shortness of breath, fluttering in the chest, and sudden dizziness.
• Fever
• Flu-like symptoms.
• Pale skin.
• Easy bleeding or bruising.
• Jaundice
• Weak pulse or very slow heart rate.
• Racing or pounding heartbeats.

Some of the drugs known to interact with Tambocor include:

• Cimetidine
• Diuretics or water pills.
• Digoxin.
• Beta-blockers such as Sotalol, Atenolol, Metoprolol, and Propranolol.
• Seizure medications.
• Other anti-arrhythmia or heart medications such as Diltiazem, Amiodarone, Nifedipine, Disopyramide, or Verapamil.

Tambocor is not safe for intake by:

• Anyone having known hypersensitivity to any of the contents of Tambocor tablets.
• Pregnant Women.
• Lactating Mothers.
• Patients with pre-existing second- or third-degree AV block or right bundle branch block when having bifascicular block, unless there is a pacemaker installed.
• People who have hearts with improper blood pumping.
• People who ever had sick sinus syndrome, a heart attack, persistent atrial fibrillation, congestive heart failure, liver disease, or low levels of potassium and magnesium in the blood.
• People suffering from cardiogenic shock.
• Infants or small children.

It is important to:

• Inform the doctor beforehand about the current intake of medications and supplements and if having any illnesses.
• Tell the doctor if you intend to get pregnant or nurse the child while taking this medication. Avoid conceiving a child or breastfeeding during the treatment course with Tambocor.
• Avoid doubling or skipping doses. A missed dose must be skipped if it's almost the time of the next dose and taken on the usual dose timing.
• Do not change the dosage or stop the intake of Tambocor without first consulting the doctor.

• Store Tambocor tablets at a controlled room temperature of about 15 to 30°C in a light-resistant, tight container.
• Keep Tambocor away from heat, moisture, and direct sunlight.

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