STENDRA (AVANAFIL)

Stendra is a common drug used to treat erectile impotence in males. The medicine must not be taken by women or children. It works on the penis, correcting erectile dysfunction by relaxing muscles present in the walls of blood vessels. This aids in increasing the flow of blood to particular areas of the body in males. The generic name for this medicine is avanafil, and it belongs to the Phosphodiesterase-5 Enzyme Inhibitors (PDE5) drug class. The medicine is approved by the Food and Drug Administration (FDA) for use. The use of this drug makes it easier for blood to enter the penis, helping males achieve a lasting erection during intercourse.

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Stendra is categorised within a class of medication known as Phosphodiesterase-5 Enzyme Inhibitors. These drugs help to impede the rapid functioning of an enzyme called phosphodiesterase type-5. This enzyme operates particularly in the penis. By slowing down the activity of this enzyme, Stendra contributes to a more controlled pace, enhancing the erectile responses in the penile area.

Erectile dysfunction is a condition where the penis does not harden and expands during sexual excitement, or when a man is not able to keep an erection. During sexual stimulation, the body’s normal response is to increase the blood flow in the penis to produce an erection and Stendra regulates this enzyme, ensuring to maintain an erection following penile stimulation by amplifying blood circulation to the area.

It is crucial to note that Stendra’s effectiveness is contingent upon physical stimulation of the penis, which is observed during sexual activity. In the absence of such stimulation, Stendra will not induce an erection.

Stendra is available in the following strengths:

• 50 mg
• 100 mg
• 200 mg

Stendra is supplied as oval, pale yellow tablets of 50, 100, and 200 mg.

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Stendra is used to treat erectile dysfunction, a condition commonly known as sexual impotence in men. As it belongs to the group of medicines called phosphodiesterase 5 (PDE5) inhibitors. The medicine operates by impending the overly rapid action of an enzyme called phosphodiesterase type-5. This enzyme works prominently in the penis.

In combination with sexual stimulation, the medicine also increases the flow of blood into the penis and helps males to get and keep an erection.

One must make a note that the medicine or drug does not protect against sexually transmitted diseases. To prevent the risk of such infections, always use an effective protection method (like condoms/dental dams) during intercourse.

The recommended starting dosage is 100mg. Stendra should be taken orally as needed as early as approximately 15 minutes before sexual activity.

The dosage of Stendra can be adjusted according to individual effectiveness and tolerance. It may be escalated to 200mg, to be taken around 15 minutes prior to engaging in sexual activity, or reduced to 50 mg taken approximately 30 minutes before sexual activity.

The goal is to find the minimum effective dose that yields the best positive results.

In the case of Stendra tablets, the route of administration is oral. It is to be taken by mouth. It is usually recommended to be swallowed with water. Taking the medicine with water ensures that the tablet is fully ingested and reaches the stomach, so it can be further absorbed into the bloodstream for the intended effect.

The specific dosages and timing instructions are provided by prescribing healthcare professionals for consuming the tablet. It can be taken with or without food. For safe results, one must always follow the doctor's instructions for the effective and safe use of the medication.

Common Stendra side effect includes:

• Headache
• Dizziness
• Diarrhea
• Constipation
• Back Pain
• Sinus Pain
• Running Nose
• Pain during erection
• Swelling in hands or feet
• Influenza
• Bronchitis
• Joint pain
• High blood pressure

In case of these symptoms stop using Stendra and seek immediate medical assistance:

• Severe dizziness
• Chest/ jaw/ left arm pain
• Nausea
• Sudden decreased vision, which includes permanent blindness, in one or both eyes

Taking Stendra in combination with certain medications, herbs, and drugs, may have harmful interactions, so it is important to consult your doctor before taking it. Some of the drugs, products, and pills that are known to interact with Stendra include:

• Adagrasib
• Azole Antifungals (Itraconazole, Ketoconazole)
• Cobicistat
• Clarithromycin
• HIV protease inhibitors (which include indinavir, and tipranavir)
• Nefazodone
• Ribociclib
• Rifampin
• Ritonavir

Before initiating Stendra or while on Stendra medication, there are a few precautions that need to be considered which include:

• If there have been any heart problems such as (a heart attack or life-threatening irregular heartbeat in the past six months) it is advised to consult the doctor before initiating the medicine.
• Diseases such as kidney failure or who are undergoing dialysis, liver disease, high or low blood pressure, dehydration, penis conditions such as angulation, fibrosis. In this condition medical consultation is required prior to initiating the use of Stendra medicine.
• It is advised to consult the doctor in case of leukaemia, multiple myeloma, eye problems, bleeding disorders, and active stomach ulcers.
• In the case of heart disease, diabetes, high cholesterol, high blood pressure, and certain eye problems there is a slightly greater chance of developing NAION if one takes Stendra.

While using Stendra tablets, there are no specific dietary restrictions or precautions. And it is always a good idea to follow a balanced and healthy diet. But it’s essential to be mindful of some key precautions, including:

• Avoid grapefruit or grapefruit juices as they can interact with certain medication which includes Aricept.
• Do not drink alcohol as it may interact with Stendra and can cause headaches.
• If one has an allergy to avanafil or any of the other ingredients present in Stendra, it is advised not to take this medication.
• Stendra can be taken with and without food, but consuming a high-fat meal can delay its onset of action. If one takes it with food, it's recommended to avoid high-fat meals.

To ensure proper storage of Stendra tablets, follow these guidelines:

• Keep it at a controlled room temperature between 20-25 degrees Celsius.
• It is recommended to keep it tightly closed in its original container.
• Keep it away from excessive heat, direct sunlight, and moisture.
• Keep it out of reach of children and pets.

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