STARLIX (NATEGLINIDE)

Starlix is a brand name for a generic diabetes medicine called Nateglinide. It is a prescription drug that got FDA approval in 2000 for use in adjunct to diet and exercise to control blood sugar levels in adults with type 2 diabetes mellitus.

Starlix tablets contain the active ingredient Nateglinide and the following inactive ingredients: sodium lauryl sulfate, carnauba wax, corn starch, sodium stearyl fumarate, copovidone, silicon dioxide, croscarmellose sodium, mannitol, and talc. Nateglinide is a white powder with the chemical name (-)-N-[(trans-4-isopropylcyclohexane) carbonyl]-D-phenylalanine. Its structural formula has no relation with oral sulfonylurea insulin secretagogues.

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Starlix belongs to the pharmacological class: Meglitinides. Starlix is a meglitinide derivative that works to control blood sugar levels in people affected by non-insulin-dependent diabetes. Meglitinides are the class of medications that stimulate the pancreas to secrete insulin in response to a meal taken by Type 2 diabetic individuals. Insulin helps reduce blood sugar levels.

Starlix tablets come in two strengths:

• 60 mg: This strength tablet is round, pink, biconvex, and beveled edge film-coated with debossing of “STARLIX” on one side and “60” on the other side. The tablet's color is because of the red iron oxide it contains.
• 120 mg: This strength tablet is ovoid, yellow, biconvex, and film-coated with debossing of “STARLIX” on one side and “120” on the other side. The tablet's color is because of the yellow iron oxide it contains.

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Starlix is given by doctors to normalize blood sugar levels in adults having Type 2 diabetes mellitus. Type 2 Diabetes Mellitus, also known as non-insulin dependent diabetes, is a long-term medical illness resulting from the problem in the way the body regulates and uses sugar as fuel.

By controlling the high blood sugar levels with Starlix, the type 2 diabetes patients would not be at risk of kidney damage, nerve problems, loss of limbs, blindness, sexual function problems, and heart attack or stroke.

• The suggested initial dose for adults with type 2 diabetes mellitus is 120 mg orally thrice a day, alone or in combination with thiazolidinedione or metformin, 1 to 30 minutes before meals.
• The recommended maintenance dose is 60 to 120 mg three times a day before meals, either as monotherapy or in combination with Thiazolidinedione or Metformin.
• To start therapy with Starlix medication in patients near goal HbA1c, the recommended dose is 60 mg three times a day before meals.

Commonly reported side effects of taking Starlix include:

• Weight gain.
• Stuffy or Runny nose.
• Cough
• Sneezing
• Flu or Cold symptoms.
• Backache
• Nausea
• Diarrhea
• Dizziness
• Joint Pain.
• Signs of hypoglycemia (chills, shaking, cold sweat, weakness).

Starlix may cause serious side effects:

• Hives
• Swelling of the face, lips, throat, or tongue.
• Difficulty breathing.
• Jaundice
• Seizure

Starlix may interact with other drugs, supplements, or substances. These include:

• Phenothiazines
• Steroids
• Isoniazid
• Diuretics
• Birth control pills or other hormone-based drugs.
• Thyroid medicine.
• Diet pills.
• Seizure medicines.
• Medicines to treat colds, asthma, or allergies.

Some drugs can lower blood sugar levels when taken along with Starlix and may lead to Hypoglycemia in Type 2 diabetes patients. These include:

• Aspirin, NSAIDs, or other Salicylates.
• Monoamine Oxidase Inhibitors.
• Sulfa drugs.
• Probenecid
• Beta-blockers.

Starlix tablet is not meant to be taken or is unsafe for use by:

• Anyone having known hypersensitivity to any of the components of Starlix tablets.
• Type 1 diabetes patients.
• Patients suffering from diabetic ketoacidosis, liver disease, or gout.
• Breastfeeding mothers.
• Anyone younger than 18 years old.

Before starting the diabetes treatment course with Starlix, the doctor recommends the patient follow these precautions:

• Avoid alcohol consumption as it can lower blood sugar levels and may interfere with the effects of Starlix.
• If pregnant or planning to conceive a child or if breastfeeding, inform the doctor beforehand.
• Inform the doctor beforehand about the current intake of medications and supplements and if having any illnesses or allergies.
• If you skip a meal, do not take Starlix, wait for the next meal.
• Get your blood sugar level checked often and quickly inform your doctor if having any side effects from taking Starlix.
• Take a proper diet, exercise well, manage weight, and seek special medical care throughout the treatment course with Starlix.
• Do not change the dosage or stop the intake of Starlix without first consulting the doctor. Avoid doubling or missing doses.

• Store Starlix tablets at controlled room temperature, preferably at 20 to 25°C away from heat and moisture.
• Dispense the tablets in a tight, light-resistant container not beyond the temperature range of 15 to 30°C.

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