RISPERDAL (RISPERIDONE)

Risperdal is a brand name for a generic antipsychotic medication: Risperidone. It is sponsored by Janssen-Cilag Pty Ltd. It is a prescription medication that got US-FDA approval in 1993 to treat schizophrenia in adolescents and adults aged 13-17 years, get relief from symptoms of manic depression (bipolar disorder) in pediatric and adolescent patients aged 10-17 years, or alleviate irritability associated with autism in children and adolescents aged 5- 16 years. Doctors may even give Risperdal tablets to adults, either alone or in combination with valproate or lithium, to temporarily provide relief from acute bipolar mania.

Each Risperdal tablet contains Risperidone as its active ingredient and the following inactive ingredients: colloidal silicon dioxide, propylene glycol, Hypromellose, sodium lauryl sulfate, lactose, microcrystalline cellulose, magnesium stearate, and cornstarch. All available strengths of Risperdal, except 1 mg Risperdal tablets also have titanium and talc. Risperidone is a white to little beige powder chemically designated as 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl] ethyl]-6,7,8,9-tetrahydro-2-methyl-4Hpyrido [ 1,2-a] pyrimidine-4-one.

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Risperdal comes under the pharmacological class: Second-generation antipsychotics- atypical antipsychotics.’

Second-generation or atypical antipsychotics are a class of drugs that block the excitatory activity of both serotonin and dopamine receptors. They are better than first-generation or typical antipsychotic drugs as they are associated with minimal or minor side effects.

Glyxambi comes in various different strengths, including:

Risperdal tablets come in six strengths and colors. All are oblong and grooved and have “JANNSEN” imprinted on one side and respective strengths mentioned on the other side.

• 0.25 mg: It is a dark yellow tablet as it contains yellow iron oxide.
• 0.5 mg: It is a red-brown tablet as it has red iron oxide.
• 1 mg: It is a white tablet.
• 2 mg: It is an orange tablet as it contains FD&C Yellow No. 6 Aluminium Lake.
• 3 mg: It is a yellow tablet as it has D&C Yellow No. 10
• 4 mg: It is a green tablet as it contains D&C Yellow No. 10 and FD&C Blue No. 2 Aluminium Lake.

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• Schizophrenia: It is a brain disease associated with symptoms like flat affect (loss of personality), catatonia, agitation, psychosis, confusion, abnormal behavior, and social withdrawal.
• Bipolar mania: Sometimes referred to as manic depression, it is characterized by cycles of depression and mania or elation. Mania is an unusually elevated state of mood. It is characterized by symptoms like increased irritability, inappropriate elation, grandiose notions, severe insomnia, disconnected and racing thoughts, increased speed and/or speech volume, more sexual desire, poor judgment, getting more energetic and active, and inappropriate social behavior.
• Autism: It is a spectrum of neurological and developmental disorders having symptoms like trouble in communication, repetitive or unusual behaviors, obsessive interests, and inappropriate social interactions.

• For Schizophrenia in adolescents, the initial dose is 0.5mg, titration is 0.5 to 1 mg, the target dose is 3 mg and the effective dose range is 1 to 6mg.
• Schizophrenia in adults initial dose is 2 mg, titration is 1 to 2 mg, the target dose is 4 to 8 mg, and the effective dose range is 4 to 16 mg.
• Bipolar mania in children and adolescents initial dose is 0.5 mg, titration is 0.5 to 1 mg, the target dose is 1 to 2.5 mg, and the effective dose range is 1 to 6 mg.
• In bipolar mania in adults, the initial dose is 2 to 3 mg, titration is 1 mg, the target dose is 1 to 6mg, and the effective dose range is 1 to 6 mg.

Risperdal is available in the form of oral tablets. Administer with meals or in between them for consistent absorption and effectiveness in managing conditions such as schizophrenia or bipolar disorder. You can take this medicine with water. Patients are advised to take the medication as directed by their healthcare provider, either as a single daily dose or divided doses, with or without meals.

Common side effects include:

• Depressed mood
• Weight gain
• Dry mouth, diarrhea, constipation, or upset stomach
• Tiredness, dizziness, or drowsiness
• Headache
• Twitching, tremors, or uncontrollable muscle movements/ extrapyramidal effects
• Anxiety, agitation, or restlessness
• Cold symptoms like sneezing, stuffy nose, or sore throat
• Fever
• Skin rash

Risperdal may cause adverse side effects, which would require prompt medical attention. Some of these are:

• Symptoms of low levels of blood platelets and white blood cells
• Breast tenderness or swelling
• High blood sugar
• Serious nervous system reaction
• Impotence
• Light-headedness
• Nipple discharge
• Painful penile erection

The intake of Risperdal tablets with certain drugs, supplements, or supplements, may make Risperdal less effective and cause serious or fatal side effects. Some drugs known to interact with Risperdal include:

• A sleeping pill
• Anti-seizures
• Anti-anxiety medications
• Blood pressure medications
• Levodopa and dopamine antagonists
• Clozapine
• Cimetidine and Ranitidine
• Fluoxetine and Paroxetine
• Carbamazepine and other enzyme inducers

Risperdal tablets are not meant for use or be safe for consumption by:

• Older adults with dementia-related psychosis
• People who have known hypersensitivity to any of the ingredients of Risperdal tablets.
• Patients suffering from liver or kidney disease, heart disease, hypertension, arrhythmia, stroke, or heart attack.
• Diabetic individuals
• Breast cancer patients
• People having low bone mineral density or low WBC count
• People facing difficulty in swallowing or experiencing severe dehydration
• Women in their last three months of pregnancy
• Breastfeeding mothers.

While on treatment course with Risperdal tablets:

• Avoid exposure to extreme temperatures.
• Keep the body well-hydrated.
• Avoid any activities that require an alert mind, as Risperidone may impair thinking abilities and reactions.
• Do not consume alcohol.
• Avoid sudden changes in postures, as Risperidone can cause dizziness or drowsiness.
• If pregnant, consult a doctor about whether it's right to take Risperdal tablets.
• Avoid drug/disease interactions with Elavil by sharing information about your current intake of drugs, and illnesses (if any) with your doctor.

• Store Risperdal tablets at a controlled temperature, below 25℃.
• Keep them in a dry, light-resistant place away from high humidity and heat as well as out of reach of small children.

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