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REXULTI

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Rexulti Information:

Rexulti is an atypical antipsychotic medication usually prescribed for the treatment of major depressive disorder in adults, Schizophrenia in adults and teenagers, and agitation associated with Dementia in Alzheimer's patients. Buy Rexulti online and manage psychosis without straining your budget!

Rexulti is a brand name for the active medication Brexpiprazole. It is a prescription drug that got FDA approval in 2015 for the treatment of Schizophrenia. In May 2023, Rexulti got another FDA clearance as the first supplemental drug for the treatment of agitation associated with dementia because of Alzheimer’s disease.

Rexulti contains Brexpiprazole as its active ingredient. Brexpiprazole belongs to a class of medications called atypical antipsychotics. It works by modulating the activity of certain neurotransmitters in the brain, including dopamine and serotonin. In schizophrenia, brexpiprazole helps to alleviate symptoms such as hallucinations, delusions, disorganized thinking, and social withdrawal. It acts as an antagonist at dopamine D2 receptors and serotonin 5-HT1A receptors, which helps to restore the balance of these neurotransmitters and improve overall mental functioning.

The following inactive ingredients are present in the medicine: corn starch, lactose monohydrate, low-substituted hydroxypropyl cellulose, hydroxypropyl cellulose, microcrystalline cellulose, hypromellose, magnesium stearate, talc., and colorants including iron oxide, titanium dioxide, and ferrosoferric oxide. Brexpiprazole is chemically designated as 7-{4-[4-(1-Benzothiophen-4-yl) piperazin-1-yl] butoxy} quinolin-2(1H)-one.

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Rexulti belongs to the pharmacological class Atypical antipsychotics, a Serotonin/Dopamine Activity Modulator (SDAM).

Serotonin-dopamine activity modulators are a class of drugs that can improve symptoms of psychiatric disorders like major depressive disorder, schizophrenia, and bipolar disorder by modulating the activity of two neurotransmitters in the brain: serotonin and dopamine. Both of these neurotransmitters help regulate mood and emotions. Dopamine is a happy hormone, responsible for pleasure sensation in addition to its role in movement, cognition, and emotions. Serotonin plays a role in the regulation of mood, behavior, cognition, sleep, and digestion.

SDAM modulates the activity of serotonin and dopamine by blocking the brain’s excitatory receptors and enhancing the activity of inhibitory receptors. Atypical antipsychotics have a lower affinity for dopamine receptors and greater serotonin receptors than typical antipsychotics.

Rexulti tablets come in 6 strengths:

  • 80.25 mg: This is the lowest strength of Rexulti tablets. It is prescribed for patients who require a very low dose of brexpiprazole.
  • 0.5 mg: This strength provides a slightly higher dose of brexpiprazole compared to the 0.25 mg strength.
  • 1 mg: The 1 mg strength is a moderate dose of brexpiprazole.
  • 2 mg: This strength offers a higher dose of brexpiprazole.
  • 3 mg: The 3 mg strength provides a further increase in the dosage of brexpiprazole.
  • 4 mg: This is the highest available strength of Rexulti tablets. It is reserved for patients who require the maximum therapeutic dose.

The specific strength prescribed will depend on various factors, including the severity of the condition being treated, individual patient response, and the healthcare provider's clinical judgment.

Rexulti drug is given by doctors for the treatment of the following medical conditions:

  • Major Depressive Disorder (MDD) in Adults: A majorly depressed adult experiences this condition that includes despair, sadness, or low mood that lasts for about 2 weeks and sometimes it can be for months to years. The patient has psychotic symptoms like delusions and hallucinations.
  • Schizophrenia in Adults and Children aged above 13 years: Schizophrenia is a lifelong mental disorder that affects one’s thinking, emotions, and behavior. Its symptoms include delusions, hallucinations, disordered speech, and thinking; unusual body movements; and lack of drive or initiative.
  • Agitation associated with Dementia in Alzheimer’s patients: Alzheimer’s disease is a progressive brain disease wherein brain cells shrink and eventually die. It mostly causes dementia. Dementia refers to a gradual decline in mental abilities like thinking, memory, and behavior that is extreme enough to impact one’s daily life. An individual having dementia may feel easily irritated to agitated.

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Dosing information for Adults with Major Depressive Disorder:

  • Prescribed Initial Dose: 0.5 mg/day or 1 mg/day (for first four days)

Dosing information for Adult Schizophrenic patients:

  • Prescribed Initial Dose: 1 mg/day (for first four days)

Dosing information for Paediatric Schizophrenic patients:

  • Prescribed Initial Dose: 0.5 mg/day (for first four days)

Dosing Information for Agitation Associated with Dementia Due to Alzheimer’s Disease in Adults:

  • Prescribed Initial Dose: 0.5 mg/day (for the first week)

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  • Rexulti tablets are for oral administration. They may be taken with or without food but with plenty of water.
  • This route of administration allows for convenient and easy ingestion of the medication. The tablets should be swallowed whole with water, and they can be taken either with or without food, according to individual preference, or as directed by a healthcare professional.

The common side effects of Rexulti include:

  • Sleepiness,
  • Weight gain,
  • Common cold symptoms,
  • Dizziness, and
  • Restlessness or akathisia- a movement disorder where one can’t remain still.

The rarely occurring serious side effects are:

  • Seizures or convulsions
  • Inability to control body temperature
  • Fainting or Falls due to orthostatic hypotension that leads to sleepiness or dizziness and slows down thinking or motor skills
  • Troubled swallowing
  • Cerebrovascular problems, including stroke, in old patients having dementia-related psychosis
  • Tardive dyskinesia- uncontrolled body movements
  • Neuroleptic malignant syndrome (NMS)
  • Metabolism issues like hyperglycemia and diabetes; hypercholesterolemia, and weight gain
  • Low count of white blood cells so more risk of infections
  • Abnormal, compulsive urges for gambling, sex, eating, and shopping
  • Decreased blood pressure (orthostatic hypotension) and fainting.

  • Rexulti tablets may interact with other drugs such as:
  • Strong/moderate CYP2D6
  • CYP3A4 inhibitors or strong CYP3A4 inducers.

So far there are 568 other drugs known to interact with Rexulti. Therefore, the patient must tell the doctor about the current intake of medications/supplements/substances before starting to take Rexulti alongside.

Rexulti is not safe for use by:

  • Pregnant women who are in the third trimester.
  • Elderly patients having dementia-related psychosis.
  • Pediatric schizophrenic patients under the age of 13 years.
  • Anyone suffering from other medical illnesses like heart problems/stroke, diabetes, blood pressure issues, seizures, high cholesterol, or others.

  • Do not abruptly stop taking Rexulti.
  • While on Rexulti medications, drink plenty of water and avoid exercising especially in hot weather.
  • Report to the doctor any new or worsening symptoms.
  • If getting pregnant during treatment with Rexulti, inform the doctor about it.
  • Avoid alcohol consumption as it can increase side effects of Rexulti such as drowsiness, dizziness, and trouble concentrating.

  • Store Rexulti tablets in their original package at a controlled temperature maintained at 20 to 25℃.
  • Do not keep the tablets at a temperature below 15℃ and above 30℃.
  • Keep them away from moisture and heat.

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Frequently Asked Questions:

Rexulti is costly because it is a new brand of medication whose generic version is not yet available. Genetic medication tends to be cheaper than brand medication. As Rexulti is a brand medication, a lot of research is put behind it to ensure its safety and effectiveness which adds to the total Rexulti cost.

Yes. Weight gain is one of the reported side effects of taking Rexulti in patients being treated for either Major Depressive Disorder or Schizophrenia. The possible reason behind weight gain could be loss of appetite and limited physical activity.

As per clinical studies done with Rexulti, for some patients results were noticeable within 1 or 2 weeks of starting the treatment. Schizophrenia and Depression patients could see final results in 6 weeks while it took 12 weeks for results to be noticed in Alzheimer’s patients having agitation associated with dementia.

Yes. Rexulti is an atypical antipsychotic- a drug class designed for the treatment of psychiatric conditions like Schizophrenia and Depression.

No. Rexulti is just a prescription medication for the treatment of psychotic symptoms in patients suffering from Schizophrenia, Major Depressive Disorder, and Alzheimer’s Disease.

Shradha Joshi

Medicine Information written by Shradha Joshi, Master in Biotechnology

Updated - September 15, 2023

DISCLAIMER: The information contained in this page is supplied to canadapharmacypro.com by third party medical content expert, and is not intended to substitute medical advice from a licensed doctor. Always make sure to consult with a doctor before ordering medication online. Do not avoid or delay seeing a healthcare provider based on what you read here.

Please note that not all products, including any referenced in this page, are shipped by our affiliated Canadian Pharmacy. We affiliate with other dispensing pharmacies, that ship product directly to our customers from the following jurisdictions: Australia, New Zealand, Mauritius, India, Canada and United Kingdom. The items in your order may be split and shipped from any other pharmacy that is listed if it is not available from the chosen pharmacy. In this event, you will be contacted and approval obtained before it is shipped. Rest assured, we only affiliate with our authorized dispensaries that procure product through reliable sources.

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