RENVELA

Renvela is a brand name for a generic phosphate binder drug Sevelamer Carbonate and a registered trademark of Genzyme Corporation. It is a prescription medication that got FDA approval in 2007 for regulating serum phosphate levels in adults and children aged below 6 years as well as older patients suffering from chronic kidney disease and are on dialysis.

Renvela tablets or oral suspension contains Sevelamer Carbonate as its active ingredient. Sevelamer carbonate is a polymeric amine, an anion exchange resin, that can bind to phosphate. It is hygroscopic and chemically designated as poly (allylamine-co-N, N'-diallyl-1,3diamino-2-hydroxypropane) carbonate salt. The function of sevelamer carbonate is to bind to dietary phosphate in the gastrointestinal tract, preventing its absorption into the bloodstream. It works by forming an insoluble complex with phosphate in the intestines, which is then excreted from the body through the feces. By reducing the absorption of phosphate from the diet, sevelamer carbonate helps to lower phosphate levels in the blood, thereby assisting in the management of hyperphosphatemia.

Renvela tablets have the following inactive ingredients: Sodium Chloride, Hypromellose, Diacetylated Monoglycerides, Zinc Stearate, and Microcrystalline Cellulose. Each packet of Renvela powder contains the following inactive ingredients: sucralose, natural and artificial citrus flavor, ferric oxide (yellow), sodium chloride, and propylene glycol alginate.

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Renvela belongs to the pharmacological class: Phosphate binders/scavengers.

• Dietary phosphate binders or phosphate scavengers are medications to treat hyperphosphatemia- abnormally high phosphate levels in the blood. These work to reduce phosphate absorption from ingested food in the gastrointestinal tract by reacting with phosphate and converting it into an insoluble compound that gets eliminated through feces.
• If phosphate binders are regularly consumed with meals, they can reduce the phosphate concentration in the blood serum. These are beneficial for patients who are suffering from end-stage renal disease/failure or iron deficiency anemia.

Renvela comes in the following forms and strengths:

• 800mg white, oval, compressed, film-coated tablets imprinted with RENVELA 800
• 0.8g and 2.4 g pale yellow powder.

Renvela is given by doctors for the treatment of hyperphosphatemia mainly seen in dialysis patients suffering from chronic kidney disease.

Hyperphosphatemia is a condition wherein blood phosphorous levels exceed the normal range. It may further cause problems like red eyes, itchy skin, hypertension, bone pain, and an increased risk of fractures because of a decline in calcium in the body caused by elevated phosphate levels. In chronic kidney disease, the kidney’s ability to eliminate phosphorous minerals from the body reduces, increasing blood phosphate levels.

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Renvela, containing the active ingredient sevelamer carbonate, is a versatile medication available in multiple forms for convenient administration. It can be taken as an oral suspension in powder form or as easy-to-swallow oral tablets.

The oral suspension offers a flexible and user-friendly option, allowing patients to mix the powder with water or other appropriate liquids to create a palatable suspension. This form is particularly beneficial for individuals who may have difficulty swallowing tablets or prefer a liquid formulation.

For those who prefer a more traditional approach, Renvela is also available in oral tablet form. These tablets are designed to be easily swallowed and can be taken with or without food, depending on individual preferences or as directed by a healthcare professional.

Common side effects may include:

• Gas, Stomach Ache.
• Indigestion, Bloating.
• Diarrhea, Constipation.
• Nausea
• Vomiting
• Loss of Appetite
• Itching
• Joint pain
• Tiredness

The serious, but rare side effects of taking Renvela are:

• Black, tarry, or Bloody Stools.
• Choking or Difficulty in Swallowing.
• Severe Constipation with Stomach Ache.
• Allergic Reactions
• Constipation that gets worse or is not clearing.

Some drugs that are known to interact with Renvela are:

• Ciprofloxacin
• Mycophenolate Mofetil

• Patients suffering from bowel obstruction.
• Patients having known hypersensitivity to Sevelamer carbonate or any other ingredients of the Renvela drug.
• Pregnant women
• Young children- below 6 years old.

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When considering or taking Renvela, the patients must take some precautions. They must:

• Avoid intake of Renvela if allergic to Sevelamer.
• Talk to a doctor to ensure the safety of Renvela medication, if they are experiencing slow digestion, an intestinal blockage or disorder, trouble swallowing, or severe.
• constipation, a stomach disorder, or have recently undergone surgery of the stomach/intestine.
• Inform the doctor if pregnant or planning of pregnancy.
• Take ciprofloxacin at least 6 hours after taking Renvela or 2 hours before taking Renvela.
• Take mycophenolate mofetil at least 2 hours before taking Renvela.
• Avoid or limit intake of foods loaded with phosphorous such as Bran cereals, lemonade, or canned iced teas; nuts and peanut butter; egg yolks, dairy products (cheese, milk, yogurt), beans, processed meats, and cola.
• Go for routine blood tests to monitor chloride and bicarbonate levels within the body while taking Renvela.
• Take Renvela with meals having low phosphate content.
• Take missed doses as and when they remember taking it with food, but skip it if it’s almost time for another dose of the day.

• Store Renvela at a controlled room temperature and protected from moisture and heat.
• Keep the room temperature maintained at 25℃, but not below 15℃ or above 30℃.
• Keep it away from the reach of children and pets.

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