PRANDIN (REPAGLINIDE)

Prandin is a brand name for a general anti-diabetic medication, Repaglinide. It is a prescription medication that got FDA approval in 2008 for the treatment of adults suffering from type 2 diabetes when taken in adjunct with a healthy diet and regular exercise.

Prandin tablets contain the active ingredient Repaglinide and the following inactive ingredients: calcium hydrogen phosphate (anhydrous), polyacrylic potassium, povidone, glycerol (85%), microcrystalline cellulose, meglumine, maize starch, poloxamer, and magnesium stearate.

Repaglinide is a white to off-white powder chemically designated as S(+)2-ethoxy-4(2((3-methyl-1-(2-(1 piperidinyl) phenyl)-butyl) amino)-2-oxoethyl) benzoic acid. It is not related to the oral sulfonylurea insulin secretagogues. Want to purchase Prandin tablets online at a discounted price? Visit CanadaPharmacyPro to buy Prandin online at an affordable price.

Prandin belongs to the pharmacological class of Meglitinides. Meglitinides are the class of antidiabetic medications that help control the blood sugar levels in type 2 diabetes patients when taken along with a proper diet and exercise regime. They work to close ATP-dependent potassium channels in functional pancreatic beta cells which further opens the calcium channels to increase the influx of calcium. The rise in intracellular calcium levels stimulates the pancreas to release insulin. Insulin helps in controlling blood sugar levels.

Prandin tablets come in two strengths:

• 1 mg: This strength tablet is round, yellow, and biconvex-shaped. It has a debossing of “745” on one side and “C” on the other side. The tablet's color is because of the yellow iron oxide it contains.
• 2 mg: This strength tablet is pink, yellow, and biconvex-shaped. It has a debossing of “747” on one side and “C” on the other side. The tablet's color is because of the red iron oxide it contains.

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Prandin is used to treat Type 2 Diabetes. Type 2 Diabetes Mellitus is a chronic medical condition wherein the body is not able to use insulin normally and therefore cannot control the levels of blood sugar. The spike in blood sugar levels can result in disorders of the immune, nervous, and circulatory systems. The medicine works by stimulating the release of insulin from the beta cells in the pancreas. This helps to decrease blood glucose levels.

The medicine also has glucose-dependent action. The medicine is more effective when blood glucose levels are higher. This is beneficial because this helps prevent low blood sugar during the phase when blood glucose levels are already normal or low.

• For diabetics who have not taken any anti-diabetic agents or whose HBA1c (glycosylated hemoglobin) is below 8%, the initial recommended dose is 0.5 mg orally with every meal or 2-4 times a day.
• For diabetics who have been previously treated with anti-diabetic agents or whose HBA1c level is 8% or above, the initial recommended dose is 1 or 2 mg orally with every meal or 2-4 times a day.
• The suggested dose range is 0.5 mg to 4 mg orally with each meal.
• The suggested maximum daily dose is 16mg.
• The patient’s dosage adjustment is done as per blood glucose response. At least one week must be taken to assess glycaemic response following each dose adjustment.

Prandin is available in the form of tablets for oral administration. Take the tablets 2 to 4 times daily, within half an hour of having a meal with enough water. Prandin's mechanism involves influencing cellular membrane potential, regulating ATP-sensitive potassium channels, and facilitating insulin release from pancreatic beta cells. So, one must closely follow the doctor's instructions on how to take Prandin.

Commonly reported Prandin side effects are:

• Low blood sugar.
• Joint Pain.
• Diarrhea
• Nausea
• Headache
• Back Pain.
• Weight Gain.
• Dizziness
• Sore throat.
• Stuffy Nose.

Serious side effects of Prandin are:

• Hives
• Troubled Breathing.
• Vomiting
• Temporary hair loss
• Blurred Vision.
• Dark-colored urine.
• swelling of the lips, face, throat, or tongue.
• Pale or Yellow skin.
• Weakness
• Confusion
• Pancreatitis

Some of the drugs known to interact with Prandin include:

• Probenecid
• Blood thinners.
• Non-steroidal anti-inflammatory drugs.
• Sulfa drugs
• Aspirin or other Salicylates.
• Beta-blockers.
• Monoamine oxidase inhibitors.
• Cyclosporine
• St. John’s wort
• Antifungal medications.
• Antibiotics
• Heart or blood pressure medications.
• Barbiturates
• Medicines for HIV/AIDS.
• Seizure medicines.
• Rifamycin

Prandin is not safe for intake by:

• Anyone having known hypersensitivity to any of the ingredients of Prandin tablets.
• Pregnant women.
• Breastfeeding mothers.
• Type 1 diabetics.
• People with diabetic ketoacidosis with or without coma.
• Patients with severe liver disease.
• Individuals who are taking gemfibrozil, NPH insulin, clopidogrel, cyclosporine, or other diabetes medication.
• Anyone aged below 18 years.

Before starting the diabetes treatment course with Prandin, the doctor recommends the patient follow these precautions:

• Avoid alcohol consumption as it can drop blood sugar levels and may interfere with the effects of Prandin.
• If pregnant or planning to conceive a child or if breastfeeding, inform the doctor beforehand.
• Inform the doctor beforehand about the current intake of medications and supplements and if having any illnesses or allergies.
• If you skip a meal, do not take Prandin, wait for the next meal.
• Get your blood sugar level checked often and quickly inform your doctor if having any side effects from taking Prandin.
• Take a proper diet, exercise well, manage weight, and seek special medical care throughout the treatment course with Prandin.
• Do not change the dosage or stop the intake of Prandin without first consulting the doctor. Avoid doubling or missing doses.

• Store Prandin tablets in tightly closed containers at room temperature, preferably between 20 to 25°C.
• Keep them away from heat and moisture and out of reach of small children.

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