ONGLYZA (SAXAGLIPTIN)

Onglyza is a prescription drug that Bristol-Myers Squibb/AstraZeneca manufactured to treat type 2 diabetes mellitus in adults and the FDA approved it in 2009. The active ingredient of Onglyza is Saxagliptin. With several trials, saxagliptin is now considered safe and efficient in the control of high sugar levels.

Saxagliptin is a dipeptidyl peptidase-4 inhibitor that averts the release of the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide to enhance glycaemic control. This results in the rise of GLP-1 levels and stimulates insulin secretion that facilitates the reduction of postprandial glucagon and glucose levels.

Saxagliptin has proven beneficial for individuals with close targets of HbA1c who often experience elevated glucose levels post meals. You can buy Onglyza online at our pharmacy at variable prices.

The advantages of Onglyza (Saxagliptin) over other anti-diabetic drugs include:

• Good harmony with other antidiabetic medications.
• Less aggressive side effects compared to other anti-diabetic drugs.
• Lower risk of hypoglycemia i.e., blood glucose level below the normal range.
• Lesser risk of cardiovascular disease.
• A neutral effect on body weight.
• Elevates erectile dysfunction.

Onglyza is an Anti-diabetic drug. Saxagliptin is the active ingredient of Onglyza that belongs to a group of drugs called dipeptidyl peptidase-IV (DPP-4) inhibitors. They are used in the treatment of type 2 diabetes mellitus.

Onglyza is available in two strengths: EQ 2.5mg base and EQ 5mg base. You will find Onglyza at different costs per strength to buy online at our pharmacy.

Taking Onglyza if you suffer from a particular medical condition may lead to any severe or fatal incident. Therefore, discussing your medical history with the doctor before starting Onglyza is crucial. Your doctor might adjust the dose of your medication according to your medical condition. If you have a history of allergic reactions to any medication before, then inform your doctor before taking this medicine. It is prudent to inform your doctor if you have any medical conditions such as chronic kidney disease, heart disease, liver disease, or neurological disorders.

• Doctors recommend a dose of 5mg (q.d.) i.e., once daily with or without food.
• It is recommended as a first-line treatment to get optimal blood glucose levels in combination with other hypoglycemic drugs or as monotherapy along with diet and exercise.
• In recent studies 5mg once daily has proven to be effective in patients with type 2 diabetes treated with diet alone, as well as in combination with adjuvant hyperglycemic medications.
• However, the dosage prescribed by the doctor completely depends on your age, medical conditions, and blood glucose levels.
• Prefer the dosage prescribed by your local physician or consult a doctor before you buy Onglyza online.

Take through the mouth. It is available in pill form. You must take Onglyza pills orally. Do not chew, break, or crush it. It comes with a thin layer of substances that induces the release of the active ingredient after reaching the stomach. Any action, such as breaking or crushing the tablet, may interfere with the mechanism of release. You may swallow it with or without water, irrespective of the time of the meal.

Most common adverse reactions are:

• Upper respiratory tract infection.
• Urinary tract infection.
• Headache

Some side effects can be severe or harmful such as:

• Acute Pancreatitis: Onglyza may cause Inflammation of the pancreas. Signs of pancreatitis include vomiting, nausea, or severe abdominal pain. Internal signs include lethal bleeding of the pancreas. This can also lead to a life-threatening condition known as necrotizing pancreatitis.
• Blindness

You must seek medical attention if you get:

• Anaphylaxis: Skin rashes, redness (bee hive pattern), itching, flaking, etc.
• Angioedema: Fluid accumulation in the deeper layers of skin that causes swelling of the face or any other body part.
• Stevens–Johnson syndrome: A rare but serious allergic reaction where several painful skin blisters are formed.

If you want to buy Onglyza online, you must also know some drugs that are not compatible with Onglyza. They can cause adverse effects when taken along with Onglyza cost. An observation by the researchers is that the combination of such medication with Onglyza leads to increased reports of hypoglycemia.

Drugs to avoid in combination with Onglyza are:

• Sulfonylureas
• Insulin
• Aspirin
• Crestor
• Atorvastatin
• Carvedilol
• Furosemide
• Amlodipine
• Allopurinol

• Pancreatitis: Individuals suffering from Pancreatitis (inflammation of the pancreas) should discontinue taking Onglyza as it can worsen the condition.
• Kidney Disease: Individuals with Kidney functioning disorders are monitored regularly. The doctor will carry out Kidney function tests to avoid the risk of sudden hypoglycemia.
• Hypersensitivity: Allergy to any of the components of the formulation of Onglyza will cause an allergic reaction. The intolerance of Onglyza can be life-threatening.
• Diabetic Ketoacidosis: Onglyza is not advisable if suffering from Diabetic Ketoacidosis and type 1 diabetes.
• Alcoholism: You should not take Onglyza if you are addicted to alcohol. Discuss the details of your alcohol intake with the doctor before you start the medication.

• Food: There is no data available that advises avoiding food that contraindicates with Onglyza. However, you must talk to your doctor about a healthy diet plan that complements the beneficial effects of Onglyza.
• Pregnant women and lactating mothers: Clinical trials in the US recommended caution. Depending upon the significance of the drug to you, the doctor will decide whether to discontinue the drug or stop breastfeeding.
• Alcoholism: Do not consume along with alcohol.
• Heart Failure: People with a history of hospitalization because of heart failure should be cautious. After initiating Onglyza, you must report any symptom of cardiovascular disease immediately to your doctor to prevent the risk of heart failure.
• Renal impairment: Inform your doctor if you are on dialysis. Onglyza can worsen the kidney functions.
• Bullous pemphigoid: There have been reports of people developing bullous pemphigoid in a post-marketing survey of Onglyza.

• Store Onglyza at a temperature between 68*F to 77*F (22*C to 25*C).
• Keep out of reach of Children and Pets.
• Do not keep it in the bathroom.
• Store in a dry place.

Onglyza prices vary on the strengths. Although Onglyza cost is expensive in local pharmacies in the U.S. we provide cheaper rates at our online pharmacy. You can buy Onglyza here at the most affordable cost. We provide Onglyza at different costs. Onglyza price may vary depending on the country you choose to order from. To buy Onglyza online at our pharmacy you must have a valid and legible prescription from your local physician.

We do not sell medication without a prescription. To place an order with us, you simply need to add your prescription, select the dosage, and checkout. In case you are facing any difficulty, then contact our customer service representative. We are happy to assist you in placing an order with us.