NORVASC

Norvasc is a brand name for a generic heart medication called Amlodipine Besylate. It is a prescription medicine that got FDA approval in 1996 to lower hypertension and treat angina pectoris. It can even treat blocked arteries of the heart- coronary artery disease.

Norvasc contains Amlodipine Besylate as its active ingredient. Amlodipine acts as a calcium channel blocker and inhibits calcium ions influx into the smooth muscle cells of the blood vessels and heart. By blocking calcium channels, Amlodipine causes vasodilation and reduces the workload on the heart. This helps lower blood pressure, improve blood flow, and help treat hypertension (high blood pressure) and angina (chest pain).

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Norvasc belongs to the pharmacological class of long-acting calcium-channel blockers and calcium ion antagonists. Calcium channel blockers are anti-anginal agents that can provide instant relief from symptoms of angina and even prevent angina attacks. This class of medicines blocks the voltage-gated calcium channels by restricting the amount of calcium entering the cardiac and smooth muscles. This leads to widening of the blood vessels, better oxygen-rich blood supply to the heart, and reduction in blood pressure.

Norvasc tablets come in the following strengths:

• 2.5mg: It is a white, flat-faced, diamond-shaped, beveled-edged tablet with “Norvasc” engraved on one side and “2.5” on the other side.
• 5mg: It is a white, flat-faced, elongated octagon-shaped, beveled-edged tablet with “Norvasc” and “5” engraved on one side and nothing on the other side.
• 10mg: It is a white, flat-faced, round, beveled-edged tablet with “Norvasc” and “10” engraved on one side and nothing on the other side.

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Doctors give Norvasc tablets for the prevention and treatment of the following medical conditions:

• Angina: It is a severe or crushing chest pain caused by an inadequate supply of oxygen to the heart muscles. It feels like pressure and suffocation just behind the breastbone. Norvasc controls chest pain by increasing the blood supply to the heart.
• Hypertension: It is the increase in blood pressure. It results in the exertion of too much force on the arteries as blood flows through them at high pressure. Norvasc helps treat hypertension in adults and children aged above 6 years when taken in adjunct with other hypertension drugs.
• Coronary artery disease: It is a heart problem characterized by the narrowing of the blood arteries and subsequent reduction in the amount of oxygen-rich blood that can flow to the heart. It happens because of plaque deposition along the arterial walls. Norvasc helps relax the arteries, and widen them so that the heart no longer has to pump so hard.

• The suggested initial adult dose for adults with angina, hypertension, or CAD is 5mg once daily. The maintenance dose is 5-10mg once daily. The maximum daily dose is 10mg once daily.
• The suggested maintenance dose for a pediatric patient is 2.5mg to 5mg daily and the maximum dose is 5mg per day.
• The suggested initial geriatric dose for hypertension is 2.5mg once a day. The maintenance dose is 2.5 to 10mg once daily and a maximum daily dose of 10mg per day.
• The suggested initial geriatric dose for angina pectoris is 5mg once a day. The maintenance dose is 5 to 10mg once daily and a maximum daily dose of 10mg per day.
• Take the tablet once, same time daily, with or without food.

Norvasc tablets are white tablets formulated for oral use. The medicine passes through the digestive system and is absorbed into the bloodstream through the walls of the stomach and intestines. From there, the medication is distributed throughout the body via the circulatory system, reaching the target tissues and organs where it exerts its therapeutic effects.

The common side effects of taking this medicine are:

• Swelling in the feet.
• Tightness in the chest area.
• Difficult breathing
• Dizziness or nausea
• Racing heartbeat
• Warm feeling
• Face redness and sometimes in the neck and upper chest area.
• Bleeding in the gum area.
• Loosening of the skin.
• Blood in the urine blurred vision.
• Chills
• Cough
• Dark yellow urine.
• Diarrhea
• Fever
• Itching of the skin.
• Swelling of the face, fingers, feet, or lower legs.
• Swollen glands
• Yellow eyes or skin
• Hives
• Numbness
• Tingling in the face, fingers, or toes.
• Red or irritated eyes.
• Sore throat
• Sweating
• Clay-colored stools
• Difficulty with speaking.
• Drooling
• Feeling of shakiness in the legs, feet, arms, and hands.

Some of the known drugs to interact with Norvasc include:

• Ketoconazole
• Simvastatin
• Ritonavir
• Itraconazole
• Cyclosporine
• Diltiazem

Norvasc tablets are not safe for use by:

• Anyone with known hypersensitivity to Amlodipine.
• Children aged under 6 years.
• People who suffer from heart problems including severe aortic stenosis, severe obstructive coronary artery disease, and heart failure or liver problems.
• Breastfeeding mothers.
• Pregnant women.

• Avoid changing postures suddenly as you may feel dizzy after taking the tablet.
• Avoid intake of Norvasc tablets with grapefruit or grapefruit juices.
• Tell the doctor before taking Norvasc tablets if you have any allergies, any illnesses, and your current intake of medication, supplements, and substances.
• If pregnant or breastfeeding, inform the doctor before starting to take Norvasc tablets.
• If having renal impairment, titrate the doses slowly.
• Avoid alcohol intake as it can further lower blood pressure.
• Do not change the dose or stop taking the prescribed dose without taking the doctor’s advice.

• Store bottles containing Norvasc tablets at a controlled temperature, within the range of 15-30℃.
• Dispense them in tight, light-restraint containers.
• Keep them away from heat and moisture and out of reach of small children.

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