NEXAVAR (SORAFENIB)

Nexavar is the brand name of an anti-neoplastic drug used to treat advanced solid cancers. FDA approved it in 2005 to treat primary kidney cancer that has failed the previous therapy with interleukin-2-based chemotherapy. They have recently approved it to treat liver cancer as well.

The active ingredient of Nexavar is Sorafenib. The generic name of Nexavar is sorafenib, however, it also has other names such as sorafenib tosylate and BAY 43-9006. Sorafenib is less expensive compared to Nexavar cost.

Sorafenib is an anti-neoplastic drug agent that targets the activities of the cancer-causing genes in the DNA. It inhibits the activities leading to tumor growth and promotes the remission of cancer. The main use of sorafenib is to treat advanced primary cancers of the liver and kidney. Another use includes monotherapy or combination with other anti-cancer drug agents.

• Nexavar (Sorafenib) is an anti-cancer drug that belongs to the Tyrosine kinase inhibitor class (TKI). Tyrosine kinase inhibitors target specific cells that cause cancer growth. They kill the cells that cause damage. They block the actions of enzymes that are responsible for disease progression. TKIs are also called tyrphostins or tyrosine phosphorylation inhibitors.
• Nexavar is a chemotherapeutic agent used in the treatment of patients with genetic mutations of genes, such as VEGFR, FGF, PDGFR, KIT, RET, CRAF, and BRAF. Therefore, it is considered targeted chemotherapy. Save more shopping at our online pharmacy on Nexavar cost.

It is available in the strength of 200mg. A single tablet of 200mg contains sorafenib tysolate as EQ 274mg base. A single blister contains 28 pills and you can buy it on variable counts from a single pack of 30 tablets up to 120 tablets. You can buy Nexavar online at our pharmacy at a variable Nexavar cost.

• Nexavar is primarily used in the advanced cancer treatment of many visceral organs. It is used in the treatment of primary renal cell cancer.

• It is also used to treat advanced hepatocellular cancer (HCC), which cannot be surgically removed.
• Additionally, patients with melanoma have also reported a good response to Nexavar. It helps control cancer growth by actively killing the cancer cells.
• It is also beneficial in the treatment of acute myeloid leukemia.
• Nexavar is indicated in patients with thyroid cancer that was refractory to radioactive iodine.

• Nexavar (Sorafenib) is prescribed at 200mg twice a day, which is equivalent to a total dose of 400mg daily.
• For a daily dosage of 800mg, it is recommended to take 2 tablets of 200mg twice.
• It is typically administered on an empty stomach and not taken with food.
• The best time to take Nexavar is at least an hour before or 2 hours after a meal.
• Consume low-fat meals if you wish to take Nexavar after it.

• Nexavar (Sorafenib) comes in pill form, which is administered orally.
• Do not crush or break it or chew it.
• Just swallow it with water on an empty stomach, at least 1 hour before the meal.
• To take Nexavar after the meal, you must wait for a gap of at least 2 hours.

Common side effects are:

• Diarrhea
• Rash
• Nausea
• Hypertension
• Fatigue
• Voice change.
• Dyspnea

Nexavar (Sorafenib) can cause some serious adverse effects that include:

• Hand-foot skin reaction (HFSR) or palmar-plantar erythrodysesthesia.
• Erythema marginatum hemorrhagic.
• Splinter subungual hemorrhages.
• Alopecia
• Pruritus
• Xerosis

Other side effects:

• Thyroid dysfunction leading to hypothyroidism.
• Cerebral hemorrhage.
• Transient ischemic attack.
• Heart failure
• Arrhythmia
• Thromboembolism
• Dru-induced Hepatitis.
• Respiratory tract infections.

• Administer Nexavar (Sorafenib) with caution, when compounds that are metabolized/eliminated by the UGT1A1 and UGT1A9 pathways are administered adjuvantly.
• Coadministration of Nexavar with docetaxel may increase docetaxel AUC.
• Taking neomycin along with Nexavar may cause a decrease in Nexavar bioavailability.
• Taking warfarin while on Nexavar therapy has led to rare bleeding events.

• Patients with a history of malignant skin cancer or skin lesions.
• Patient with a history of hypersensitivity.
• Pregnant females are warned against Nexavar.
• Hypertensive patient.
• Patient with gastro-intestinal perforation disease
• It interferes with wound healing therefore, it must be held during a major surgery.

• Metabolism of CYP3A4 is hindered by grapefruit. Therefore, consuming grapefruit products may elevate the serum levels of Nexavar.
• On the other hand, the metabolism of CYP3A4 is encouraged with St. John’s wort herb. This reduces the serum levels of Nexavar.
• Please read and follow all the safety instructions before use.
• Pregnant women should be cautious as Nexavar can cause hazards to the unborn child.
• Breastfeeding and lactating women should avoid Nexavar and consult the doctor before taking this medication.
• Can cause toxicity on prolonged use resulting in organ damage.
• Avoid taking this medication while eating.
• Avoid taking this medication with alcohol.
• In case of accidental overdose, please get immediate medical attention.

• Keep in a cool and dry place.
• Store at room temperature.
• Do not keep in moist places such as a bathroom.
• Do not keep under direct sunlight.
• Do not flush in the toilet or sink.
• Do not use it after the expiration date on the blister.
• Avoid contact with children.
• Keep away from pets.

Nexavar is available to shop online at our online pharmacy. You can buy Nexavar online at CanadaPharmacyPro. Nexavar prices vary on the number of pills you order. We provide Nexavar costs at reasonable rates at our online pharmacy. You can buy Nexavar here at the most affordable cost. Nexavar price may vary depending on the country you choose to order from.

Save more by shopping its generic sorafenib that comes in cheaper Nexavar cost at our pharmacy. To buy Nexavar online at our pharmacy you must have a valid and legible prescription from your local physician. We do not sell medication without a prescription.

To place an order with us, you simply need to add your prescription and choose the country that is giving you the best Nexava cost. Select the dosage, and checkout through a simple payment gateway. In case you are facing any difficulty, then contact our customer service representative. We are happy to assist you in placing an order with us.