LOZOL (INDAPAMIDE)

Lozol is a brand name for a generic medication called Indapamide. It is a prescription drug that got FDA approval for the treatment of hypertension (high blood pressure) and edema (salt and fluid retention) in patients suffering from congestive heart failure. Lozol tablets contain Indapamide as its active ingredient and the following inactive ingredients: corn starch, microcrystalline cellulose, hypromellose, coloring agent, pregelatinized starch, lactose, polyethylene glycol, magnesium stearate, and talc.

Indapamide has only a single sulfonamide group and no thiazide ring system. It is white to yellow-white crystalline powder chemically designated as 1-(4-chloro-3­ sulfamoylbenzamido)-2-methylindoline. It has both a polar sulfamoyl chlorobenzamide moiety and a lipid-soluble methylinodiline moiety but chemically differs from thiazides as it contains only a single sulfonamide group and no thiazide ring system. Want to purchase Lozol tablets at a discounted price? Buy Lozol Online with CanadaPharmacyPro at the best price.

Lozol belongs to the pharmacological class: Thiazide Diuretics. Thiazide diuretics, also known as thiazide water pills, are a class of drugs that works to increase urine flow (diuresis) by inhibiting the electrolyte (sodium/chloride) co-transporter located in the functional unit of the kidney- the distal convoluted tubule of a nephron. They reduce sodium and water reabsorption which increases the loss of fluid in the urine further decreasing the extracellular fluid and plasma volume. This reduces the cardiac output and lowers blood pressure.

Lozol tablets come in 1.25 mg and 2.5mg strengths. The tablets are orange, octagon-shaped, and film-coated having markings R and 7. Their supply is done in bottles of 100 or 1000 tablets.

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Lozol tablets are given by doctors for the following indications:

• Hypertension: Lozol, either alone or in combination with other anti-hypertensive drugs can help treat hypertension. Hypertension is a medical condition wherein the blood flows in the blood vessels at a pressure of 140/90 or higher. It puts a load on the heart and arteries, and if left untreated for long, it can lead to improper functioning of the cardiovascular system. This increases the risk of damage to blood vessels of the heart, brain, and kidneys, resulting in heart failure/attack, stroke, or kidney failure. Lozol can help control blood pressure and reduce the likelihood of such risks and complications.
• Edema of congestive heart failure: Lozol can help treat swelling or puffiness of tissues just underneath the skin which is caused by fluid build-up in the tissues. The fluid retention is usually seen in the legs and arms, often as a result of venous insufficiency or congestive heart failure. Congestive heart failure is a chronic condition wherein the heart cannot normally pump to allow proper blood supply to every part of the body, thereby causing blood and fluid accumulation in the legs and lungs over time.

• The suggested initial dosage for adults suffering from hypertension is a single 1.25 mg tablet taken once in the morning daily. If the response to the initial dosage is unsatisfactory after four weeks, the daily single dose may be increased to 2.5 mg.
• The suggested initial dosage for adults suffering from edema of congestive heart failure is a single 2.5 mg tablet taken once in the morning daily.

Lozol XL is available in the form of tablets meant for oral administration. It helps to reduce high blood pressure and swelling/edema caused as a result of heart failure. The tablets are taken once a day, in the morning time. One must take medicine as advised by the doctor for the best results. Oral intake helps the medicine be absorbed through the gastrointestinal tract, leading to predictable and consistent blood levels.

Some of the commonly reported side effects of Lozol include:

• Headache
• Dizziness
• Skin rash.
• Anxiety
• Swollen glands.
• Fever with or without chills.
• Agitation
• Stuffy or runny nose.
• Sneezing
• Dark urine.
• Light-colored stools.
• Unusual bruising or bleeding.
• Jaundice

Adverse effects of taking Lozol include:

• Vision problems or loss.
• Irregular or fast heartbeats, shortness of breath, etc.
• Severe confusion.
• Difficulty walking.
• Slurred speech.
• Infection
• Severe pain.
• Rhinitis

Some drugs known to show unwanted interactions with Lozol include:

• Lithium
• Baclofen
• Steroids
• Oral insulin or anti-diabetic medication.
• Aspirin and other salicylates.
• NSAIDs
• ACE inhibitors.
• Chloroquine
• Amiodarone
• Clarithromycin
• Droperidol
• Dofetilide
• Thioridazine

Intake of Lozol tablets is unsafe for:

• Pregnant or breastfeeding women.
• Small children.
• Anyone having known hypersensitivity to any contents of Lozol or other sulfonamide-derived drugs.
• Patients suffering from illnesses like anuria, diabetes, gout, heart rhythm problems, hyperuricemia, liver disease, electrolyte imbalance, glaucoma, kidney disease, myopia, sympathectomy, systemic lupus erythematosus, or myopia.
• Patients who have recently undergone a sympathectomy.

Before starting the course of treatment with Lozol take note of the following precautions:

• Avoid drug/disease interactions with Lozol by sharing information about your current intake of drugs, and illnesses (if any) with your doctor.
• Avoid sudden discontinuation of intake of Lozol tablets, overdose, or skipping of dose.
• Inform the doctor beforehand if pregnant, planning childbearing, or breastfeeding.
• Avoid alcohol intake and use of tobacco.
• Limit intake of food rich in sodium and potassium.

• Store Lozol supplies bottles tightly closed at controlled room temperature, preferably at 20-25℃.
• Keep the supply bottles away from heat and moisture and out of reach of small children.
• The tablets may get spoilt or their efficacy may become low below 15℃ and above 35℃.

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