LOVAZA (OMEGA-3 ACID ETHYL ESTERS)

Lovaza is a brand name for a generic medication called Omega-3-acid ethyl esters. It is an FDA-cleared prescription drug used for lowering triglyceride levels in the blood of adult patients suffering from severe hypertriglyceridemia. It works effectively only when a proper lipid-lowering diet and exercise regime is followed.

This medicine is composed of omega-3 polyunsaturated fatty acids. This is extracted from fish oils, vegetable oils, or oil from other plant sources. It also contains ethyl esters of omega-3 fatty acids- eicosapentaenoic acid and docosahexaenoic acid. Both of these are active ingredients and contain 4mg α-tocopherol (in a carrier of soybean oil), glycerol, gelatin, and purified water which makes up the capsule shell as inactive ingredients.

Lovaza belongs to the pharmacological class of Lipid-lowering, nutraceutical products. Lipid-lowering agents are the class of drugs that help reduce the chances of heart attacks, by lowering the out-of-range lipids level in the blood, including the blood cholesterol and triglycerides that could cause arteriosclerosis.

Omega-3 fatty acids ethyl esters in Lovaza drug works as lipid-lowering agents by reducing triglycerides synthesis in the liver, increasing beta-oxidation in the liver, and increasing the lipoprotein lipase activity as well as wasting away of triglycerides in the bloodstream. Lovaza is a nutraceutical product that is used as a supplement to a lipid-lowering diet while treating severe hypertriglyceridemia and preventing risks of heart attacks.

Lovaza comes in single strength: 1 gram, packaged in bottles of 120. Each one-gram capsule of Lovaza is transparent, soft, gelatin-based, and filled with a minimum of 900mg of the omega-3 fatty acids ethyl esters (light yellow colored fish oil). They bear the labeling “GS FH2”.

Lovaza is given by healthcare providers along with a recommended diet for the treatment of severe hypertriglyceridemia. Severe hypertriglyceridemia refers to a medical condition where triglyceride levels in the blood go equal to or greater than 500mg/dL. Patients suffering from this condition are more likely to suffer from serious health issues like acute pancreatitis and heart attack if left untreated or not timely treated.

Lovaza works to reduce the levels of triglycerides and bad cholesterol while maintaining or raising good cholesterol, thereby preventing serious health issues. However, the effect of Lovaza on the risk of pancreatitis and cardiovascular mortality and morbidity is yet to be determined.

• The suggested daily dose of Lovaza is 4 grams daily.
• The dose can be taken either as 4 capsules together once a day or as 2 capsules together two times a day, with meals.
• The dose should be as required to lower the assessed triglyceride level in the blood and should be initiated only when having a proper lipid-lowering diet.

Lovaza capsules are meant for oral administration. Swallow the capsules wholly with food. Do not crush, chew, dissolve, or open the capsules. It is important to swallow the medicine as a whole so that it reaches the stomach and is further absorbed in the bloodstream so that it can function effectively to lower the risk of heart attacks.

Common unwanted effects of taking Lovaza:

• Stomach upset, Diarrhea, or Constipation.
• Skin rash
• Burping
• Appetite loss
• Backache
• Dry mouth
• Taste perversion

Some of the serious side effects of taking Lovaza:

• Irregular heartbeats
• Chest pain
• Dyspepsia- indigestion
• Signs of allergic reactions
• Black or tarry stools
• Easy bruising or bleeding
• Eructation
• Vomiting that looks like coffee grounds.

Some drugs known to interact with Lovaza include:

• Birth control pills or hormone replacement medications.
• Beta-blockers
• Blood thinners
• Medicines to prevent blood clots- including ticlopidine, alteplase, dipyridamole, clopidogrel, and others.
• Diuretics or water pills.

Lovaza is not meant to be taken by:

• Anyone with known hypersensitivity to Lovaza or any of its ingredients as well as fish/shellfish or soy.
• People who have or ever had a heart rhythm disorder, diabetes, bleeding issues, anemia, a pancreas disorder, liver disease or hepatic impairment, or underactive thyroid.
• Children

Before starting to take Lovaza capsules, keep in mind and follow these precautions:

• If pregnant or planning to childbearing, take Lovaza only when a doctor prescribes it.
• Consult a doctor for Lovaza, before nursing the child and know of its safety for use alongside breastfeeding.
• Avoid drug/disease interactions with Lovaza by sharing information about your current intake of drugs, supplements, and substances; and illnesses (if any) with your doctor.
• Avoid taking Lovaza, if you are allergic to it or allergic to fish/shellfish or soy.
• Have lipid-lowering meals while taking Lovaza.
• Avoid sudden discontinuation of intake of Lovaza, its overdose, or skipping of dose.
• Avoid alcohol intake and consumption of herbal/health supplements like capsicum, clove, ginkgo, garlic, ginger, red clover, turmeric, willow, and others.

• Store Lovaza capsules at controlled room temperature, preferably at 20-25℃, away from heat, direct light, and moisture.
• The capsules may get spoiled or their efficacy may become low below 15℃ and above 30℃.
• Keep them out of reach of small children.

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