LESCOL XL (FLUVASTATIN)

Lescol XL is a brand name for a generic statin medication called Fluvastatin Sodium extended-release tablets. It is a prescription medication that got initial FDA approval in 2000 for use as adjunctive therapy to diet to alter lipid content in the blood.

Lescol XL tablets contain Fluvastatin Sodium as its active ingredient and following inactive ingredients such as titanium dioxide, yellow iron oxide, microcrystalline cellulose, magnesium stearate, povidone, hydroxypropyl cellulose, hydroxypropyl methylcellulose, polyethylene glycol 8000, and potassium bicarbonate.

Its use is to lower the level of triglycerides and low-density lipoprotein (bad cholesterol) and increase high-density lipoprotein (good cholesterol) in the blood. The drug is even given to slow down the build-up of fatty deposits in the blood vessels (called atherosclerosis) and reduce the risk of heart complications in patients suffering from coronary heart disease.

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Lescol XL belongs to the pharmacological class: Statins; Lipid-lowering agents and HMG-CoA Reductase Inhibitors. Statins are a class of medications that help reduce LDL cholesterol production. These work by blocking the activity of an enzyme called HMG-CoA reductase. This enzyme has a role in the synthesis of mevalonate, a natural substance that the body utilizes to make sterol, including cholesterol.

Lescol XL comes in single strength: 80mg. The 80mg tablets are yellow, round, slightly biconvex, film-coated, and have beveled edges. They have the debossing of “LESCOL XL” on one side and “80” on the other side. These tablets are available in bottles of 30 and 100.

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Lescol XL is given by doctors as an adjunctive therapy to diet for the following indications:

• Elevated total cholesterol, low-density lipoprotein, apolipoprotein B, and triglycerides and low levels of high-density lipoprotein in the blood of adult patients with primary hypercholesterolemia and mixed dyslipidemia.
• Elevated total cholesterol, apolipoprotein B, and low-density lipoprotein in the post-menarcheal girls and boys of 10-16 years of age with heterozygous familial hypercholesterolemia after the failure of a reasonable trial of diet therapy.
• Coronary Heart Disease: Lescol XL helps delay the progression of atherosclerosis (fat plaque buildup on the blood vessel wall) and the need for revascularization procedures.

• The suggested dosage range of Lescol XL is 20 mg to 80 mg per day.
• The recommended initial dose for adults is 80 mg which is taken as one tablet daily.
• The recommended initial dose for children is 20 mg.

Lescol XL is available in the form of a tablet with a formulation meant for oral use. Swallow this extended-release tablet as a whole with a glass of water with or without food. Do not break, crush, or chew the tablet. This allows the medicine to be absorbed into the patient's bloodstream through the digestive tract. Many people find it easier to comply with oral medication compared to other routes of administration. This leads to better adherence to treatment plans and helps improve health outcomes.

Common Lescol XL side effects include:

• Nausea
• Muscle pain.
• Headache
• Stomach ache.
• Indigestion (Dyspepsia).

Some of the adverse side effects of intake of Lescol XL tablets include:

• Myalgia- muscular pain or muscle weakness in the neck, back, hips, and shoulder.
• Allergic reaction.
• Breakdown of skeletal muscle tissue, resulting in kidney failure.
• Kidney problems.
• Liver problems.

Some drugs known to show interactions with Lescol XL include:

• Niacin
• Cyclosporine
• Fluconazole
• Glyburide
• Concomitant lipid-lowering therapies.
• Phenytoin
• Warfarin and Coumarin derivatives.
• Colchicine
• Heart medications.
• Seizure medications.
• Diabetes medicine.
• Antibiotic
• Antifungal

Lescol XL is not meant to be safe for:

• Anyone having known hypersensitivity to any ingredient of the medication.
• Women who are pregnant or considering getting pregnant.
• Breastfeeding mothers.
• Patients who have active liver disease or unexplained, constant elevations in the serum transaminases.
• Individuals who have kidney disease, muscle pain or weakness, a thyroid disorder, or diabetes.
• Anyone with conditions where the major abnormality is an elevation of VLDL, chylomicrons, or IDL (hyperlipoproteinemia Types I, III, IV, or V).
• Alcohol abusers.
• Children younger than 10 years.

• Before starting the course of treatment with Lescol XL take note of the following precautions to avoid experiencing serious side effects of the medication.
• Avoid eating foods that are high in bad cholesterol or unhealthy fats and regularly exercise and manage weight.
• Avoid alcohol consumption as it can increase the levels of triglycerides in the blood and may increase the risk of liver damage.
• Avoid drug/disease interactions with Lescol XL by sharing information about your current intake of drugs, and illnesses (if any) with your doctor.
• Avoid sudden discontinuation of intake of Lescol XL tablets, overdose, or skipping of dose.

• Store Lescol XL tablets at controlled room temperature, preferably at 20-25℃.
• Keep the supply bottles away from heat and moisture and out of reach of small children.
• The tablets may get spoilt or their efficacy may become low below 15℃ and above 35℃.

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