JENTADUETO

Jentadueto is a brand name for a combination of two generic antihyperglycemic drugs: Linagliptin and Metformin. It is a prescription medication with a trademark of Boehringer Ingelheim International GmbH & Co. KG. The drug got US-FDA approval in 2012 for use with diet and exercise to improve blood sugar control in case of Type 2 diabetes mellitus in adults.

Each coated tablet of Jentadueto contains Linagliptin and Metformin Hydrochloride as its active ingredients. Linagliptin is an orally active inhibitor of the DPP (dipeptidyl peptidase)-4 enzyme, chemically designated as 1H-Purine-2,6-dione, 8-[(3R)-3-amino-1-piperidinyl]-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2quinazolinyl)methyl]. The chemical name of metformin hydrochloride is N, N-dimethylimidodicarbonimidic diamide hydrochloride. It is not chemically/pharmacologically related to other classes of oral antihyperglycemic index.

The tablet core contains the following inactive ingredients: polyethylene oxide, magnesium stearate, and Hypromellose. Its coating has the following inactive ingredients: polyethylene glycol, propylene glycol, hydroxypropyl cellulose, ferrosoferric oxide, Hypromellose, talc, arginine, isopropyl alcohol, ferric oxide yellow (2.5 mg/1000 mg), carnauba wax, and titanium dioxide.

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Jentadueto belongs to the pharmacological class: Antidiabetic combinations, Antidiabetic Biguanides/Dipeptidyl Peptidase-IV Inhibitors.

Antidiabetic combinations are medications having two or more classes of antidiabetic agents, with different mechanisms of action, in a single dose. Just with one dose, there can be improved glycemic control. Antidiabetic Biguanides/Dipeptidyl Peptidase-IV Inhibitors are antidiabetic combinations that help control hyperglycemia in people with Type 2 diabetes.

Jentadueto tablets come in three strengths. All of them are oral, biconvex tablets with Boehringer Ingelheim logo on one side but they vary in color. The strengths are

• 2.5 mg linagliptin/500 mg metformin HCl: This strength tablet is light yellow and has “D2/500” debossed on one side.
• 2.5 mg linagliptin/850 mg metformin HCl: This strength tablet is light orange and has “D2/850” debossed on one side.
• 2.5 mg linagliptin/1000 mg metformin HCl: This strength tablet is light pink and has “D2/1000” debossed on one side. 

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Jentadueto is given by the doctor to manage symptoms of Type 2 diabetes mellitus.

Type 2 diabetes, earlier known as non-insulin dependent diabetes or adult diabetes, is the most common form of diabetes. This medical condition is defined by persistently high levels of glucose in the blood.

It occurs when the body cells do not properly process ingested sugars (glucose). The pancreas produces insufficient levels of insulin- the hormone responsible for controlling blood sugar levels. With little or no insulin, the glucose is not able to enter the body cells to derive energy instead it accumulates in the blood. There is insulin resistance, meaning the body is not able to use insulin effectively. 

The symptoms of Type 2 Diabetes include:

• Extreme hunger
• Frequent infections.
• Excessive thirst and hunger.
• Frequent urination.
• Fatigue
• Unexplained weight loss.
• Burning pain or tingling sensation in legs, feet, hands, or other parts of the body.
• Slow wound healing
• Blurred vision.

• The recommended starting dose of Jentadueto for adult patients who are not currently treated with metformin HCl is 2.5 mg linagliptin/500 mg metformin HCl, twice daily with meals.
• The recommended dose of Jentadueto for adult patients who have had treatment earlier with metformin HCl is 2.5 mg linagliptin/current dose of metformin HCl, twice daily with meals.
• The recommended dose of Jentadueto for adult patients who have previously received treatment separately with linagliptin and metformin HCl is the same dose for each component.
• The suggested dosage of Jentadueto varies among patients depending on both effectiveness and tolerability. Gradually, the doctor escalates the dose of Jentadueto tablets for the patient, while not exceeding the maximum recommended daily dose of 2.5 mg linagliptin/1000 mg metformin HCl.

Jentadueto is available in the form of tablets for oral administration. Patients should swallow the tablets with water as directed by their healthcare provider. The patient must take the medicine with meals to control blood sugar levels. The oral administration helps the medicine to be absorbed through the digestive system after being taken by mouth.

The most common side effects include:

• Stuffy or Runny nose.
• Sore throat
• Diarrhoea

Jentadueto may cause adverse side effects, some of which are:

• Lactic acidosis (lactic acid build-up in the blood).
• Pancreatitis (pancreas inflammation).
• Very low blood sugar level (hypoglycemia).
• Hypersensitivity/Allergic reactions including troubled breathing, hives, swelling of face, lips, throat, or tongue; and others.
• Vitamin B12 deficiency.
• Joint and muscle pain.
• Skin reactions like itchy skin and red/purple skin rash with blistering and peeling.
• Lightheadedness
• Dizziness
• Weakness
• Abnormal heart rate.
• Cough and sinus pain.
• Loss of appetite
• Intense pain in upper stomach.
• Nausea
• Vomiting
• Fever
• Weight gain.

Some drugs known to show interactions with Jentadueto include:

• Carbonic Anhydrase Inhibitors.
• Insulin or Insulin Secretagogues.
• Drugs affecting glycemic control.
• Drugs that reduce metformin clearance.
• Drugs inducers of CYP3A4 enzymes or P-glycoprotein.

Jentadueto is not meant to be taken by:

• Anyone younger than 18 years.
• Elderly who are aged above 65 years.
• Patients suffering from severe renal impairment, liver problems, gallstones, heart problems, or pancreatitis.
• People having type 1 diabetes, metabolic acidosis, diabetic ketoacidosis, or high triglycerides.
• People who are known to have hypersensitivity to linagliptin, metformin, or any of the drug ingredients.

• Avoid alcohol consumption while on Jentadueto as it can lower blood sugar and may increase the chances of lactic acidosis.
• Avoid taking Jentadueto tablets on an empty stomach, overdosing on them, or missing the dose.
• Always have a proper diet and regularly exercise while on treatment with Jentadueto tablets.
• If a nursing mother or pregnant or planning pregnancy, tell your doctor beforehand.
• Avoid drug/disease interactions with Xeloda by sharing information about your current intake of drugs, and illnesses (if any) with your doctor.

Store Jentadueto capsules at controlled room temperature, preferably at 20-25℃, away from heat and high humidity.

The capsules may get spoilt or their efficacy may become low below 15℃ and above 30℃.

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