GEODON

Geodon is a brand name for the generic medication Ziprasidone. It is a registered trademark of Viatris Speciality LLC- Viatris Pharmaceutical Company. This drug got FDA approval in 2001 for the treatment of Schizophrenia and manic symptoms or mixed episodes of Bipolar I Disorder. In combination with valproate or lithium, Geodon can help manage bipolar disorder. The doctors prescribe this drug as an oral treatment for adults and children aged above 10 years.

Geodon capsules contain monohydrochloride, monohydrate salt of Ziprasidone as its active ingredient, and the following inactive ingredients: lactose, magnesium stearate, and pregelatinized starch. Ziprasidone hydrochloride monohydrate is a white to slightly pink powder chemically designated as ziprasidone hydrochloride monohydrate is 5-[2-[4-(1,2- benzothiazole-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one, monohydrochloride, monohydrate.

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Geodon belongs to the pharmacological class: Atypical Antipsychotics (or Second-Generation Antipsychotics).

Atypical antipsychotics are the recently discovered class of antipsychotics. The designing of such a class of drugs was done to relieve symptoms like hearing voices, hallucinations, delusions, or confused thoughts/paranoia typically associated with some psychiatric condition.

Atypical antipsychotics like Geodon work by blocking the excitatory activity of neurotransmitters: Dopamine and Serotonin. These chemicals released by neurons transmit nerve signals for regulating many functions including behavior, mood, pleasure sensation, learning, and memory.

Geodon capsules come in four strengths of varying color and size:

• 20mg (blue/white)
• 40mg (blue/blue)
• 60mg (white/white)
• 80mg (blue/white)

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• Schizophrenia: It is a chronic mental disorder, a serious mental illness wherein patients abnormally interpret reality. Its symptoms include hallucinations, extremely disordered thinking, behavioral changes, and delusions that can be disabling and impair daily functioning. Geodon capsules are taken to treat symptoms of Schizophrenia.
• Bipolar disorder: It is a serious mental health condition, formerly known as manic depression. It is associated with extreme mood fluctuations including feeling emotionally high (mania or hypomania) and emotionally low (depression). Geodon capsules can help treat Bipolar I Disorder. It is an acute monotherapy for manic episodes lasting for at least a week, severe manic symptoms requiring prompt medical care, and depressive episodes lasting for at least 2 weeks.

• The initial recommended dosage for Schizophrenia patients is 20 mg twice a day. The daily dosage may be up to 80mg twice daily. The doctor may make dosage adjustments at intervals of 2 days.
• The initial recommended dosage for acute monotherapy of manic or mixed episodes is 40 mg twice a day. After a 2-day dose, the daily dosage is 60 mg or 80 mg twice daily. The doctor may make dosage adjustments between 40 mg and 80 mg twice daily, based on the patient’s tolerance level and drug efficacy.
• For maintenance treatment of Bipolar I Disorder, continue with the same recommended dose (within 40-80 mg daily), upon which the patient initially stabilized. 

Geodon capsules are specifically designed for oral administration, and it is essential to follow specific instructions for their consumption. To ensure optimal effectiveness, swallow the capsules whole, with a meal. It is crucial to avoid any attempt to crush, chew, or open the capsules, as this can alter the medicine's functionality and may lead to undesirable effects or reduced efficacy.

The common side effects seen in adults are:

• Dizziness
• Constipation
• Upset stomach or Nausea.
• Restlessness or inability to sit still.
• Feeling sleepy or extremely tired/drowsy.
• Diarrhea
• Vision problems
• Rashes
• New or worsening cough/runny nose.
• Difficulty swallowing
• Headache

Some of the serious side effects are:

• Shortness of breath.
• Mouth or skin sores.
• Cough
• Sore throat
• Fluttering in the chest.
• Pounding or fast heartbeat.
• Sudden light-headed feeling.
• Fever
• Increased thirst and urination.
• Sweating
• Dry mouth
• Very stiff muscles
• Confusion
• Agitation
• Fruity breath odor.

Some drugs known to interact with Geodon include:

• Tacrolimus
• Anagrelide
• Methadone
• Antidepressants such as citalopram and escitalopram.
• Medications that cause sleepiness such as allergy/cold medications, sleeping pills, narcotics, muscle relaxers, and medications for anxiety, seizures, and depression.
• Blood pressure medications.
• Water pills (diuretics).
• Certain anti-nausea medications like droperidol, dolasetron, or ondansetron.
• Some antibiotics including clarithromycin, azithromycin, moxifloxacin, levofloxacin, erythromycin, and pentamidine.
• Certain cancer medications such as vandetanib and arsenic trioxide.
• Certain anti-malaria drugs including chloroquine, mefloquine, and halofantrine.
• Other antipsychotic medications such as thioridazine, chlorpromazine, pimozide, mesoridazine, and haloperidol.
• Heart rhythm medications such as ibutilide, amiodarone, flecainide, disopyramide, dronedarone, dofetilide, sotalol, and quinidine.

The intake of Geodon capsules is not safe in the following cases:

• Children aged below 10 years.
• Known hypersensitivity to ziprasidone or any of the ingredients of Geodon.
• Breastfeeding
• Having a known medical history of QT prolongation.
• Recent acute myocardial infarction or heart stroke/attack.
• Uncompensated heart failure.
• A heart rhythm disorder.
• Dementia-related psychosis in elderly.
• A bone marrow or blood cell disorder.
• Epilepsy or Seizures.
• Alzheimer’s disease
• Breast cancer
• Low levels of potassium or magnesium in the blood.
• Diabetes
• Liver Disease
• Kidney disease
• Last 3 months of pregnancy.

Before starting to take Geodon capsules, keep in mind and follow these precautions:

• Tell your doctor if you are pregnant or planning for it, breastfeeding, have any allergies, are taking other drugs/supplements, or have any medical condition.
• Avoid alcohol consumption.
• Do not eat meals having more than 500 calories.
• Drink plenty of water to avoid dehydration or side effects.
• Avoid grapefruit or grapefruit juice as it can affect the metabolization of the medicine.
• Do not drive while taking this medicine as it can cause drowsiness and dizziness.

• Store Geodon capsules at controlled room temperature, preferably at 20-25℃, away from heat, direct light, and moisture.
• The capsules may get spoiled or their efficacy may become low below 15℃ and above 30℃.
• Keep away from direct sunlight, pets, and kids.

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