ESTRACE (ESTRADIOL)

Estrace is a brand name for a generic hormone-based drug called Estradiol. This prescription medication got FDA approval in 2004 for use in relieving menopause symptoms such as vaginal changes and hot flashes; preventing osteoporosis (bone loss) in menopausal women; and replacing estrogen in women suffering from conditions like ovarian failure that leads to a lack of natural estrogen in the body. Sometimes doctors might prescribe Estrace as a part of cancer treatment in both women and men.

Estrace tablets contain micronized Estradiol as an active ingredient and the following inactive ingredients: corn starch, dibasic calcium phosphate, magnesium stearate, lactose monohydrate, colloidal silicon dioxide, acacia, talc, and sodium starch glycolate. Estradiol is a white, crystalline solid with the chemical name extra-1,3,5, (10)-triene-3, 17ß-diol. Are you looking for low-price tagged Estrace tablets? Buy Estrace Online with CanadaPharmacyPro at a discounted price.

Estrace (Estradiol) belongs to the pharmacological class: Estrogen Derivatives. Estradiol is a derivative of endogenous estrogen. Estrogen is naturally present in both men and women but is also available in synthetic form. It is mainly a female sex hormone contributing to breast and reproductive health in females, among other essential bodily processes.

Estradiol, a form of estrogen, is a class of medications used as a supplement in females having a deficiency of natural estrogen, which usually is seen at the time of menopause. It binds to estrogen receptors in cells and functions similarly to estrogen. It works by lowering the levels of gonadotropin-releasing hormone, luteinizing hormone, and follicular stimulating hormone in postmenopausal women.

Estrace tablets come in three strengths, in supply bottles of 100 tablets:

• 0.5 mg: This strength tablet is oval, white to off-white, flat-faced, and beveled-edged. It has a scoring of 720/1/2 on one side and a debossing of WC on the other side.
• 1 mg: This strength tablet is oval, light purple, flat-faced, and beveled-edged. It has a scoring of 721/1 on one side and a debossing of WC on the other side. The color of the tablet is because of the following inactive ingredients: FD&C blue no. 1 aluminum lake and D&C red no. 27 aluminum lake.
• 2 mg: This strength tablet is oval, green, flat-faced, and beveled-edged. It has a scoring of 722/2 on one side and a debossing of WC on the other side. The color of the tablet is because of the following inactive ingredients: FD&C blue no. 1 aluminum lake and FD&C yellow no. 5 (tartrazine) aluminum lake.

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Estrace tablets are given by doctors for the following indications:

• Treatment of moderate to severe hot flashes (sudden strong feelings of heat and sweating or warmth in the neck, face, and chest) associated with menopause.
• Treatment of dryness, burning, and itching in or around the vagina as well as difficulty in urination or burning on peeing associated with menopause.
• Treatment of certain medical conditions in which ovaries of women are unable to naturally produce enough estrogen.
• Treatment of unusual vaginal bleeding because of hormonal imbalance when a doctor has not identified any serious cause of the bleeding.
• Treatment of certain cancers like breast cancer in special situations in appropriately selected women and men with metastatic disease (for palliation only).
• Treatment of advanced androgen-dependent prostate cancer (for palliation only).
• Prevention of bone loss (osteoporosis) in menopausal women.

• The usual suggested initial dosage range is 1 to 2 mg daily for the treatment of moderate to severe hot flashes, and vaginal and vulvar atrophy associated with menopause or female hypoestrogenism. Administration of the tablet should be cyclic, for instance, 3 weeks continue intake and then a 1-week gap.
• The usual suggested dose for the treatment of breast cancer, for palliation only, is 10 mg thrice a day daily for at least 3 months.
• The usual recommended dose for treatment of advanced androgen-dependent prostate carcinoma, for palliation only, is 1 to 2 mg thrice a day daily.
• There is no single lowest effective dose of Estrace determined so far for the prevention of osteoporosis postmenopausal.

Estrace is available in the form of a tablet with a formulation meant for oral use. Swallow this medicine as a whole with a glass of water. Do not break, crush, or chew the medicine. This oral intake allows the medicine to be absorbed into the patient's bloodstream through the digestive tract. Oral medicines can be taken at home without medical supervision, this provides patients with flexibility in managing their treatment schedules.

Commonly reported Estrace side effects include:

• Nausea
• Vomiting
• Pain in the breasts.
• Vaginal spotting or irregular vaginal bleeding.
• Hair loss.
• High blood sugar and blood pressure.
• Liver problems.
• Yeast infection of the vagina.
• Dark spots on the skin, particularly on the face.
• Fluid retention.
• Headache

The less common but serious side effects include:

• Stroke
• Heart attack.
• Dementia
• Gallbladder disease.
• Cancer of the breast, ovaries, or uterus.
• Changes in speech.
• Lumps formation in the breasts.
• Leg pain.
• Vision changes.
• Shortness of breath.

Some drugs known to show interactions with Estrace include:

• Anticoagulants (Blood thinners).
• Fish Oil (omega-3 polyunsaturated fatty acids).
• Thyroid medication.
• Glyburide
• Tamoxifen
• Toremifene
• Aromatase inhibitors.
• Fezolinetant
• Ospemifene
• Cymbalta (Duloxetine).
• Ambien (Zolpidem).
• Aspirin
• Insulin or oral diabetes medicine.

Intake of Estrace tablets is unsafe for:

• Anyone having known hypersensitivity or allergy to estradiol or any other contents of Estrace tablets.
• Women who are pregnant or thinking of conceiving a child.
• Patients suffering from liver disease, kidney disease, heart disease, gallbladder disease, thyroid disorder, seizure disorder, asthma, uterine fibroid or endometriosis, lupus, migraines, hereditary angioedema, or porphyria.
• Women who are experiencing undiagnosed unusual vaginal bleeding.
• Individuals who have high amounts of serum calcium.
• Individuals who have past medical records of heart attack, stroke, blood clot or hormone-related cancer, or cancer of the uterus/cervix, vagina, or breast.
• People who are at increased risk of having blood clots due to genetic blood disorders or heart problems.
• Breastfeeding mothers.
• Children, adolescents, and young adults.

Before starting the course of treatment with Estrace take note of the following precautions:

• Avoid smoking and alcohol intake while taking Estrace tablets as they can increase the risk of blood clots, heart attack, or stroke.
• Avoid intake of grapefruit products.
• Avoid drug/disease interactions with Estrace by sharing information about your current intake of drugs, and illnesses (if any) with your doctor.
• Avoid sudden discontinuation of intake of Estrace tablets, overdose, or skipping of dose.

• Store Estrace tablets at controlled room temperature, preferably at 20-25℃.
• Keep the supply bottles away from heat, light, and moisture and out of reach of small children. The tablets may get spoilt or their efficacy may become low below 15℃ and above 35℃.

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