ELDEPRYL

Eldepryl (Selegiline) is a brand name for a generic medication called Selegiline. It is a prescription drug that got FDA approval in 1999 as an adjunct treatment for patients with Parkinson’s disease. Doctors give it as monotherapy if the patient is in an early phase of the disease and otherwise as combination therapy with levodopa-carbidopa- another prescription drug for Parkinson’s disease, to manage the symptoms of the disease.

Eldepryl contains Selegiline Hydrochloride as its active ingredient. Selegiline hydrochloride belongs to a class of drugs called monoamine oxidase inhibitors (MAOIs), specifically a selective irreversible inhibitor of MAO-B.

The main function of Selegiline Hydrochloride is to inhibit the enzyme monoamine oxidase-B (MAO-B) in the brain. MAO-B is responsible for the breakdown of certain chemicals in the brain, including dopamine. By inhibiting MAO-B, selegiline hydrochloride increases the levels of dopamine in the brain, which helps to improve the symptoms of Parkinson's disease. The following inactive ingredients in this medicine are lactose, citric acid, microcrystalline cellulose, and magnesium stearate. Selegiline hydrochloride is a laevorotatory acetylenic derivative of phenethylamine (l-deprenyl). It is a white to near-white crystalline powder chemically designated as (R)-(-)-N,2-dimethyl-N-2-propynylphenethylamine hydrochloride.

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Eldepryl belongs to the pharmacological class, Monoamine Oxidase (MAO-B) Type B Inhibitor, Dopaminergic anti-parkinsonism agent.

• The dopaminergic anti-parkinsonism agent works to replace dopamine in the central nervous system by either releasing dopamine or mimicking the action of dopamine or else preventing dopamine degradation. Generally, these dopamine-replacing drugs are given in combination with peripherally acting dopa carboxylase inhibitors. This is to prevent the metabolism of the levodopa drug to dopamine in the peripheral region. Dopamine receptor agonists function to mimic the action of dopamine by binding to dopamine receptors.
• Selective Monoamine Oxidase Type B Inhibitor works to prevent dopamine degradation by binding to the enzyme MAO-B and blocking its activity.
• Thus, these drugs are useful in the treatment of Parkinson’s disease resulting from a deficiency of dopamine in the basal ganglia of the brain.

Eldepryl capsules come in only 5mg strength. These hard capsules are aqua blue colored and imprinted with “Eldepryl 5mg” on the lower part (called body) and the Somerset logo on the upper part (called a cap). The appropriate strength and dosage of Eldepryl will be determined by your healthcare professional based on your condition and needs.

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• Eldepryl is given by doctors to treat symptoms associated with Parkinson’s disease.
• Parkinson’s disease is a chronic, degenerative movement disorder wherein the brain cells functioning in controlling body movements die and cause changes in how one feels, acts, and moves. It interferes with daily life activities but is not a life-threatening condition. It occurs because of the degradation of dopamine- a neurotransmitter in the brain that controls thoughts, movements, and feelings.   
• The signs and symptoms of Parkinson’s disease include joint stiffness, jerky movements, difficulty writing/speaking, tremors, trouble in moving positions, less facial emotions or blinking, problems in keeping the body in balance, and hunched or shuffling position while walking.

The suggested maximum daily dose of Eldepryl is 10mg. The patients must take one 5mg capsule at breakfast and another 5mg capsule at lunch.

This dosing regimen helps ensure a steady and consistent level of selegiline hydrochloride in the body throughout the day, which is important for optimizing its therapeutic effects.

By dividing the total daily dose into two separate administrations, the medication can continuously inhibit the enzyme monoamine oxidase-B, leading to sustained elevation of dopamine levels in the brain.

Eldepryl is available in the form of capsules. This drug is meant for oral administration. The capsules must be swallowed as a whole.

To take Eldepryl, one should have a glass of water ready. Simply place the capsule in the mouth and swallow it with water, without breaking or manipulating the capsule in any way. This ensures that the medication is delivered intact to the stomach, where it can be absorbed into the bloodstream.

Taking Eldepryl with or without food is generally determined by the healthcare professional based on the individual's specific needs and any potential interactions with other medications. It's important to follow the instructions provided by the doctor or pharmacist regarding the timing of Eldepryl administration in relation to meals.  

Common side effects may include:

• Stomach Pain, Heartburn, Diarrhea, Gas, Constipation.
• Nausea, Vomiting.
• Dizziness, Weakness, Fainting.
• Dry Mouth
• Skin Rash or Irritated Skin.
• Sleep issues (including Insomnia).

Some of the adverse side effects are:

• Runny or stuffy nose.
• Mouth sores or ulcers.
• Backache
• Light-headedness as if passing out.
• Difficulty in breathing
• Hallucinations, confusion, abnormal behavior, or unusual thoughts.
• Uncontrolled muscular movements or intense tremors.
• Signs of high serotonin level in the body (if taken along with antidepressant).
• Severe hypertension
• Allergic reactions
• Pain while swallowing (if taken while using Zelapar).

Some drugs known to interact with Eldepryl include:

• Diet pills
• Cold medications containing Ephedrine, Phenylephrine, or Pseudoephedrine.
• Cough medications containing Dextromethorphan.
• Methadone
• St. John’s wort
• Tramadol
• Other MAO inhibitors-including linezolid, selegiline, rasagiline, methylene blue injection, tranylcypromine, isocarboxazid, and others
• Rifampin
• Carbamazepine
• Phenobarbital
• Nafcillin
• Narcotic pain medications like meperidine
• Antidepressants.

Eldepryl capsules are not safe to be taken by:

• Anyone having an allergy to any ingredient of Eldepryl or has taken fluoxetine within the first 5 weeks.
• People who have kidney or liver disease or hypertension.Small children.

• Consult a doctor before starting to take Eldepryl capsules to avoid any unwanted or adverse side effects of using the medicine. Tell the doctor if you are breastfeeding or pregnant beforehand. Also, discuss what medications are safe to take along with Eldepryl if already taking any drugs.
• Avoid alcohol consumption while on a prescribed course of Eldepryl.
• While taking Eldepryl and even after 14 days of stopping the use of medicine, avoid having foods rich in tyramine. This includes foods like non-pasteurized or tap beer; soybeans, tofu, soya sauce, sauerkraut, fava beans; aged or fermented meats, air-dried meats; spoilt or improperly stored beef, fish, or poultry; aged cheeses; yeast extracts.
• Be careful while doing any activities that require an alert mind such as driving until sure what side effects Eldepryl can cause to you.
• Avoid sudden stopping of intake of Eldepryl capsules or overdosing.

• Store Eldepryl capsules in their original packaging at room temperature below 25℃. 
• Keep them protected from light, excess heat, and moisture as well as out of reach of small children. 

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