ELAVIL

Elavil is a brand name for a generic medicine: Amitriptyline. It is a prescription antidepressant drug with sedative effects. It got FDA approval in 1961 to provide relief from depression symptoms, more likely endogenous depression. Doctors may give this medicine for treating anxiety, chronic nerve pain, eating disorders, and panic disorders.

Each Elavil tablet contains Amitriptyline Hydrochloride as its active ingredient and the following inactive ingredients: microcrystalline cellulose, colloidal silicon dioxide, sodium starch glycolate, hypromellose, titanium dioxide, lactose monohydrate, polysorbate, magnesium stearate, and polyethylene glycol. Amitriptyline Hydrochloride is an odorless, white crystalline compound with the chemical name 3-(10,11-dihydro-5H-dibenzo [a,d] cycloheptene-5-ylidene)-N,N-dimethyl-1- propanamine hydrochloride.

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Elavil belongs to the pharmacological class: Psychotherapeutic combos(Tricyclic antidepressants)

Psychotherapeutic combos are combination psychiatric medications that help treat depression associated with psychiatric disorders like bipolar disorder or schizophrenia. They are formulated with antidepressant, antianxiety, and antipsychotic agents.

Tricyclic antidepressants (TCAs) are a component of psychotherapeutic combo formulation. They help regulate the activities and levels of neurotransmitters: Norepinephrine and Serotonin in the brain, by preventing their reuptake by neurons.

Norepinephrine helps modulate emotional response and serotonin contributes to well-being, appetite, good mood, and a well-regulated internal clock. TCAs even block the actions of other neurotransmitters such as histamine and acetylcholine.

Elavil tablets come in 6 strengths. All of them vary in color. They are unscoured and film-coated with the debossing of “V” on one side.

• 10 mg: This strength tablet is round with a debossing of “2101” on one side. It has FD&C blue #1 lake which makes it blue-colored.
• 25 mg: This strength tablet is round with a debossing of “2102” on one side. It has FD&C blue #2 lake and D&C yellow #10 lake which gives it a yellow color.
• 50 mg: This strength tablet is round and beige with a debossing of “2103” on one side. It has synthetic red iron oxide, synthetic black iron oxide, and synthetic yellow iron oxide.
• 75 mg: This strength tablet is round with a debossing of “2104” on one side. It has FD&C yellow #6 lake that gives the tablet an orange color.
• 100 mg: This strength tablet is round with a debossing of “2105” on one side. It has D&C red #33 lake and FD&C red #40 lake, thereby giving it a mauve color.
• 150 mg: This strength tablet is capsule-shaped and blue-colored with a debossing of “2106” on one side.

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Elavil tablets are given by doctors to treat symptoms of depression. The signs and symptoms of depression include:

• Restlessness, irritability, or withdrawal feeling.
• Feeling worthless, discouraged, hopeless, or guilty.
• Fatigue
• Changes in appetite or weight loss/gain.
• Sleep problems
• Difficulty concentrating, doing daily tasks, remembering things, or making decisions.
• Having thoughts of self-killing or hurting.

• The usual, initial recommended dose is 75 mg daily in divided doses. It can be gradually increased after careful noting of the patient’s clinical response and any evidence of intolerance to the Elavil tablet.
• The maintenance recommended dose is 40 to 100 mg per day, as a single dose at bedtime.
• The recommended maximum dose is 150 mg/day.

Elavil is available in the form of tablets for oral administration. Take a single tablet once a day, preferably at bedtime. You can take Elavil with or without food, but it's generally a good idea to take it with a meal if it upsets your stomach.

The intake of Elavil tablets may cause mild or serious side effects. The common side effects include:

• Constipation
• Increased hunger, Weight gain.
• Dry mouth
• Drowsiness

Other side effects include:

• Unusual taste
• Nausea
• Vomiting
• Blurred vision
• Itching or Rashes.
• Dizziness
• Headache

Elavil may cause adverse side effects, which would require prompt medical attention. Some of these are:

• Difficulty urinating.
• Painful, swollen breasts.
• Reduced sex drive or impotence, or having orgasm difficulty.
• Seizures
• Jaundice
• Fainting
• Irregular or pounding heartbeat.
• Fever
• Muscle stiffness
• Passing out of black stools.
• Mask-like facial expressions.
• Serious allergic reactions.

Some drugs known to show interactions with Elavil include:

• Sleeping pills
• Narcotic painkillers.
• Anticonvulsants
• Antidepressants
• Antipsychotics
• Antihistamines
• Muscle relaxants
• Diabetes medications like Insulin.
• Thyroid medications like Levothyroxine.
• Blood thinners like Warfarin
• Heart rhythm medications like Quinidine.
• MAO inhibitors like Tranylcypromine
• Hypertension medications or beta-blockers like Atenolol.
• Drugs to treat overactive bladder
• Medications to treat stomach issues, irritable bowel syndrome, or motion sickness.

Elavil is not meant to be safe for:

• Anyone under 12 years old.
• Breastfeeding mothers.
• Patients who have shown hypersensitivity to Amitriptyline Hydrochloride or other ingredients of Elavil.
• Patients who concomitantly use monoamine oxidase inhibitor (MAOI) with Elavil or think of taking Elavil within 14 days of stopping intake of MAOIs.
• Patients having coronary artery disease, hypertension, or a history of heart stroke, heart attack, blood clots, or seizures.
• Patients suffering from liver disease, heart disease, glaucoma, psychosis, diabetes, bipolar disorder, or urination problems.
• People having suicidal thoughts or drug addiction.
• Patients who are in the acute recovery phase after having a myocardial infarction.

• If pregnant, consult a doctor if taking Elavil is right.
• Avoid drug/disease interactions with Elavil by sharing information about your current intake of drugs, and illnesses (if any) with your doctor.
• Avoid alcohol intake, serious or life-threatening side effects can occur.
• Avoid driving or performing any hazardous activity, until the reactions of the Elavil are known to you.
• Avoid sun exposure or use tanning beds as Elavil intake may make sunburn easier.
• Avoid sudden discontinuation of intake of Elavil tablet, overdose, or skipping of dose.

• Store Elavil tablets at controlled room temperature, preferably at 20-25℃.
• Dispense them in a tightly closed, light-resistant container and keep the container away from heat and high humidity.
• The tablets may get spoilt or their efficacy may become low below 15℃ and above 30℃.

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