DESYREL (TRAZODONE)

Desyrel is a brand name for a generic medication: Trazodone Hydrochloride. It is a prescription antidepressant drug that got FDA approval in 1981 for the treatment of major depressive disorder.

Each tablet of Desyrel contains trazodone hydrochloride as its active ingredient. Trazodone Hydrochloride is a triazolopyridine derivative, chemically designated as 2-[3-[4-(3-chlorophenyl)-1- piperazinyl] propyl]-1,2,4-triazolo [4,3-a] pyridine-3 (2H)-one hydrochloride.

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Desyrel belongs to the pharmacological class Phenylpiperazine antidepressants, SSRI/Antagonist.

Phenylpiperazine antidepressants are the form of antidepressants that act as inhibitors of serotonin (5-HT2) reuptake or/and serotonin receptor blockers. This inhibitor or blocker has a different mechanism of action in treating depression.

Desyrel tablets come in 4 strengths. All of them are white, scored tablets:

• 50 mg: This strength tablet is round, film-coated, with a one-sided bisection of “50”, and debossing of “P 005”.
• 100 mg: This strength tablet is round, film-coated, with a one-sided bisection of “100”, and debossing of “P 006”. It contains the same inactive ingredients as 50 mg tablets.
• 150 mg: This strength tablet is rectangular and trisected on both sides. It has one-sided debossing of “P 007” and three times debossing of “50” on the other side, with a bisect on each edge.
• 300 mg: It has one-sided debossing of three times “100” and bisection as well as debossing of “P 008” on the other side. In addition to the inactive ingredients of 150 mg tablets, it contains sodium starch glycolate.

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Desyrel tablets are given by doctors to adult patients suffering from major depressive disorder (MDD). Major Depressive Disorder or major/clinical depression is a mental health condition having prominent symptoms of persistent, severe low mood, sense of despair, or profound sadness. It sometimes shows up as irritability.

During a major depressive episode, the patient can experience psychotic symptoms such as delusions and hallucinations. The symptoms are long-lived, they stay at least for 2 weeks but usually, they last for months or even years. They significantly impact daily life. The potential causes include a combination of psychological, biological, and social sources of distress.

• The recommended initial dose of Desyrel is 150 mg/day in divided doses to be taken shortly after a meal or snack. Every 3-4 days, the dose of Desyrel may be increased gradually by 50mg/day after noting the clinical response of the patient and any evidence of drug intolerance. After the patients show an adequate response, the patients can gradually reduce their dosage and eventually discontinue the use of Desyrel.
• The recommended maximum dose is 400mg/day in divided doses for outpatients.
• The recommended maximum dose is 600mg/day in divided doses for hospitalized patients who are more severely depressed.

Desyrel is available in the form of tablets for oral administration. Take the medicine with water. The tablet can be swallowed as a whole or taken in parts after breaking it along the score line. This scoreline helps the patient to split the tablet into two equal parts.

This is useful if the doctor has prescribed a dose that is different from the standard tablet strength. One can use a pill splitter or a sharp, clean knife to evenly split the medicine.

Common side effects include:

• Nausea
• Vomiting
• Diarrhea or Constipation.
• Fatigue
• Drowsiness
• Weight changes
• Aching muscles
• Headache
• Dry mouth or bad taste.
• Changes in sexual ability and interest.

Desyrel may cause adverse side effects, some of which are:

• Painful penile erection or erection lasting for long hours.
• Changes in thoughts and behavior.
• Abnormal heartbeats.
• Shortness of breath.
• Nasal congestion/ Stuffy nose.
• Edema
• Blurred vision
• Sudden dizziness
• Syncope
• Easy skin bruising or unusual bleeding.
• Signs of low sodium in the body.
• Serotonin syndrome symptoms.
• Signs of allergic reactions.

Some drugs known to show interactions with Desyrel include:

• Other antidepressants
• Tramadol
• A water pill- diuretic.
• Blood thinners like Coumadin, Warfarin, and Jantoven.
• Phenytoin or Digoxin.
• CYP3A4 inhibitors or inducers.
• HIV medications
• Antifungals
• St John’s wort
• Medications that can treat mood disorders, anxiety, or mental illnesses like Schizophrenia.
• Drugs that treat migraines like Maxalt, Sumatriptan, and Imitrex.

Desyrel tablet is not meant for:

• Anyone aged below 18 years old.
• Patients suffering from liver or kidney disease, heart disease or recent heart attack, long QT syndrome, a bleeding/blood clotting disorder, narrow-angle glaucoma, bipolar disorder (manic depression), or epilepsy or seizures.
• Patients who concomitantly use monoamine oxidase inhibitor (MAOI) with Desyrel or take Desyrel within 14 days of stopping intake of MAOIs.
• People having suicidal thoughts or drug addiction.
• People who are known to have hypersensitivity to any ingredients of Desyrel.

• Store Desyrel tablets at controlled room temperature, preferably at 20-25℃.
• Dispense them in a tightly closed, light-resistant container and keep the container away from heat and high humidity.
• The tablets may get spoilt or their efficacy may become low below 15℃ and above 30℃.

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