CRESTOR

Crestor is a brand name for a generic cholesterol-lowering medication called Rosuvastatin. It is a prescription drug that got FDA approval in 2003 to manage levels of lipids in the blood of patients having high cholesterol and mixed hyperlipidemia. It is given by doctors to lower bad cholesterol and triglyceride levels and at the same time increase good cholesterol levels in the blood of adults or children aged above 8 years.

Crestor contains rosuvastatin calcium as its active ingredient. Rosuvastatin calcium is a white, amorphous, hydrophilic powder. It is synthetic cholesterol-lowering agent chemically designated as bis [(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methyl sulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid] calcium salt. The following inactive ingredients present in this medicine are: crospovidone NF, microcrystalline cellulose NF, titanium dioxide USP, yellow ferric oxide, triacetin NF, lactose monohydrate NF, hypromellose NF, tribasic calcium phosphate NF, red ferric oxide NF, and magnesium stearate NF.

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Crestor belongs to the pharmacological class: Statins

Statins, also known as HMG-CoA Reductase Inhibitors, are a class of medicines that works to reduce diet and exercise-resistant cholesterol levels in the body. These work by blocking an enzyme called HMG-CoA reductase involved in the mevalonate pathway that produces sterols, including cholesterol.

Crestor comes in the form of tablets with the following strengths:

• 5 mg: It is a yellow, biconvex, round, film-coated tablet debossed with “5” on one side and “ZD4522” on the other.
• 10 mg: It is a pink, biconvex, round, film-coated tablet debossed with “10” on one side and “ZD4522” on the other.
• 20 mg: It is a pink, biconvex, round, film-coated tablet debossed with “20” on one side and “ZD4522” on the other.
• 40 mg: It is a pink, biconvex, oval, film-coated tablet debossed with “40” on one side and “ZD4522” on the other.

The FDA-approved use of this drug is for the following medical conditions:

• Mixed hyperlipidemia: It is an inherited disorder wherein there is a higher-than-normal range of lipids (cholesterol and fats) in the body. Crestor can manage the lipids levels in such conditions and prevent cardiovascular events like heart attack and stroke.
• Familial hypercholesterolemia: It is a genetic condition characterized by high levels of bad cholesterol or low-density lipoprotein. It can be heterozygous or homozygous. Crestor can lower the cholesterol levels in this inherited type of high cholesterol.
• High triglyceride levels: Triglycerides are the most common type of body fat whose high levels can lead to main health issues. Crestor can help keep triglyceride levels in the normal range.
• Type 3 Hyperlipoproteinemia/ Dysbetalipoproteinemia: It is a common disorder wherein the body is unable to break down fats or lipids within the body. Crestor can lower lipid levels in the body and treat this disorder.
• Atherosclerosis: It is a common heart condition that happens when fat gets deposited on the arterial walls and narrows the arteries, thereby restricting blood flow. Crestor can help reduce cholesterol levels, slow the worsening of this condition, and prevent heart attack or stroke.

The suggested dose ranges from 5 to 40 mg daily with or without food.

• The prescribed initial dose for adults with Hyperlipoproteinemia including Type II A, IIB, and IV is 5 to 10 mg daily and the prescribed maintenance dose is 5 to 40 mg once daily. These suggested doses are the same to prevent cardiovascular disease.
• The suggested initial dose for adults with Homozygous Familial Hypercholesterolemia is 20 mg once daily and the suggested maintenance dose is 20 to 40 mg once daily.
• The prescribed initial geriatric dose for hyperlipidemia is 5mg once daily and the maintenance dose is 5 to 20 mg once a day.
• The suggested dose range for pediatric patients with Heterozygous Familial Hypercholesterolemia is 5 to 20 mg once a day.

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Crestor is available as a tablet for oral administration. This route of administration allows for convenient and easy ingestion of the medication, making it accessible to patients. When taking Crestor orally, it is important to follow the prescribed dosage instructions provided by your healthcare provider to ensure optimal effectiveness and safety.

The common side effects of Crestor may include:

• Headache
• Sleep issues (insomnia or nightmares)
• Depression
• Joint pain, muscle aches, and pains
• Abdominal pain, indigestion, diarrhea, constipation
• Nausea

Crestor may even cause adverse side effects. Some of them include:

• Unexplained muscle pain, weakness, or tenderness.
• Liver problems- symptoms include dark urine, jaundice, loss of appetite, upper stomach pain, and tiredness.
• Memory problems or confusion.
• Increased levels of blood sugar.
• Blood and protein in the urine.

Some drugs known to interact with Crestor include:

• Other statins like Gemfibrozil and Fenofibrate.
• Birth control pills
• Immunosuppressants like Cyclosporine
• Anti-viral drugs such as Lopinavir, Sofosbuvir, Dasabuvir, Glecaprevir, Elbasvir, and others.
• Antifungals such as Keyoconazole, Itraconazole, and Fluconazole.
• Coumarin anticogaulants like Warfarin.
• Nicotinic acid or Niacin
• Colchicine
• Teriflunomide
• Fostamatinib
• Febuxostat
• Capmatinib
• Tafamidis
• Darolutamide
• Regorafenib

Crestor is not right for everyone. It’s unsafe for:

• People suffering from liver, thyroid, or kidney problems; unexplained muscle aches or weakness.
• Pregnant or breastfeeding women.
• People who are of age 65 years or older.
• Children below 8 years of age.
• Alcohol or drug abuser.
• Individuals who are allergic to any content in the formulation of Crestor.

• Take Crestor along with a low-fat diet and water at the same time daily. Also, exercise regularly, about half an hour daily.
• Avoid alcohol consumption in conjunction with Crestor medicine. It can raise levels of triglycerides in the body and may lead to liver damage.
• Avoid having antacids without taking advice from the doctor. If recommended, take antacids after 2 hours of taking Crestor.
• Inform the doctor about your current intake of medicines and if you have any illnesses before starting to take Crestor.
• Do not take Crestor if allergic to rosuvastatin, pregnant, or breastfeeding.
• Make sure to tell your doctor if of Asian Descent as the Crestor absorption rate is higher in people of Asian Descent.
• Do not stop taking Crestor unless a doctor advises you to do so.

• Store Crestor at a controlled room temperature, preferably 20 to 25℃, not out of the range of 15 to 30℃.
• Keep the tablets in their original package away from excess moisture and direct light.

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