COLAZAL

Colazal is a brand name for an anti-inflammatory generic medicine called Balsalazide. It is a prescription drug that got FDA approval in 2000 for the treatment of active ulcerative colitis in adults and children aged at least 5 years.

Colazal contains Balsalazide disodium as its active ingredient. Balsalazide disodium is primarily used for the treatment of mild to moderate ulcerative colitis, a type of inflammatory bowel disease (IBD). It also works by exerting its therapeutic effects directly in the colon (large intestine). The following inactive ingredients are present in the medicine: magnesium stearate and colloidal silicon dioxide.

Balsalazide disodium is a stable, orange to yellow, microcrystalline powder with chemical name (E)-5-[[-4-[[(2-carboxyethyl) amino] carbonyl] phenyl] azo]-2-hydroxybenzoic acid, disodium salt, dihydrate. It is a pro medicine which when enters the colon gets enzymatically cleaved to produce mesalamine. Mesalamine is an anti-inflammatory drug chemically designated as 5-amino salicylic acid.

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Colazal belongs to the pharmacological class: 5-amino salicylates.

5-amino salicylates are the anti-inflammatory class of medicines that can treat inflammatory bowel disease, active ulcerative colitis, mild to moderate Crohn’s disease, and rheumatoid arthritis. These work by blocking the activity of enzymes lipoxygenase and cyclooxygenase that play a role in the production of prostaglandins- the chemicals produced in inflammatory disease.

Colazal is a 5-amino salicylic acid derivative that can reduce symptoms of ulcerative colitis such as rectal bleeding, diarrhea, and stomach pain by lowering prostaglandins production and subsequent inflammation of the colon.

• Colazal is available in capsule form, with each capsule containing 750 mg of Balsalazide Disodium. It's important to note that the active ingredient in Colazal, Balsalazide Disodium, undergoes a conversion process in the colon, where it is metabolized into its active form, Mesalamine.
• The 750 mg dose of Balsalazide Disodium is equivalent to approximately 267 mg of Mesalamine. This conversion is facilitated by bacterial enzymes present in the colon. Once converted to mesalamine, it exerts its therapeutic effects by targeting the inflamed tissues in the gastrointestinal tract.

Colazal is indicated for the treatment of active ulcerative colitis.

• Ulcerative Colitis is a chronic colon disease, a type of inflammatory bowel disease, characterized by inflammation and the formation of ulcers in the inner lining of the colon. Usually, it occurs in people aged between 15-30 years. 
• Its signs and symptoms include diarrhea with or without blood/mucus discharge, urgent bowel movements, intermittent rectal bleeding, bloating or abdominal cramps/tenderness; and weight loss, fever, loss of appetite, or fatigue.

• The suggested dose for treatment of active ulcerative colitis is one 750mg capsule, thrice a day, or three 750 mg capsules three times a day for up to 8 weeks.
• The recommended dose is the same for both adult patients as well as pediatric patients aged between 5-17 years.   
• Take Colazal capsules with or without food and with an adequate amount of water.

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Cleocin is frequently administered using the following routes:

• Oral: Cleocin is available as pills or capsules that must be taken orally and with water.
• Topical: For the treatment of some skin infections, such as acne, Cleocin is also offered as a topical solution, gel, or lotion. The afflicted skin region is treated immediately with the topical formulation.
• Intravenous (IV): Cleocin can be given intravenously in more serious cases of infection or when oral administration is not an option. This entails using an IV line to administer the drug straight into a vein.

The intake of Colazal capsules may lead to mild or adverse side effects. The side effects usually reported by adult patients may include:

• Mild or Occasional Nausea.
• Vomiting
• Diarrhea
• Headache
• Abdominal pain or joint pain (Arthralgia).
• Insomnia
• Loss of appetite
• Runny nose, sore throat, fever, or other cold symptoms.
• Respiratory infection.

The common side effects seen in pediatric patients may include:

• Headache
• Diarrhea
• Vomiting
• Abdominal pain
• Pyrexia
• Ulcerative colitis
• Nasopharyngitis.

Some serious side effects of taking Colazal capsules are:

• Allergic reactions
• Kidney problems including swelling, little or no urination, and weight gain
• Liver problems including dark urine, upper stomach pain, jaundice, and clay-colored stools
• Painful urination or burning sensation while urinating
• Anemia
• Worsening of ulcerative colitis symptoms including abdominal cramps, fever, bloody diarrhea, and stomach pain.

Some drugs/supplements known to interact with Colazal include:

• Azathioprine
• Celecoxib
• Mercaptopurine
• Mesalamine
• Metformin
• Omeprazole
• Ambien
• Amlodipine
• Cymbalta
• Prednisone
• Folic acid
• Fish oil
• Vitamin B12 and Vitamin D3
• Infliximab
• Tramadol

Intake of Colazal capsules is not safe for:

• Patients who are allergic to Balsalazide or mesalamine, aspirin, or other salicylates including Tricosal, Pamprin, Kaopectate, Trilisate, and others.
• Patients who have other illnesses like kidney disease, liver disease, or a stomach condition known as Pyloric Stenosis.
• Children aged under 5 years.

• If pregnant or planning of pregnancy, inform the doctor and take Colazal capsules only when prescribed. If pregnant and having active ulcerative colitis, you are at greater risk of having premature delivery or giving birth to a child with low birth weight.
• If a lactating mother, tell the doctor if noticing diarrhea in the nursing baby.
• Follow all the directions given on the medicine label and instructions given by the doctor on how to take Colazal capsules.
• Tell the doctor about all your medical conditions, current intake of medications or supplements, and allergies (if any).
• If on a low-salt diet, inform a doctor before taking Colazal capsules as these contain sodium.
• Follow the doctor’s instructions about any food, beverages, or activity restrictions.
• Do not take Colazal capsules by crushing, breaking, chewing, or cutting them. If you are taking the capsule contents only, do not save the apple sauce and medicine mixture for later use.
• While taking Colazal capsules, sun-protect your skin by applying sunscreen of high SPF and wearing sun-protective clothing as this drug can increase the photosensitivity of the skin.
• Do not take excessive doses of Colazal capsules as it may cause salicylate toxicity. Even if you have missed a dose, do not take a double dose. 

• Store Colazal capsules at controlled room temperature, preferably at 20-25℃.
• Avoid keeping the capsules at temperatures out of range of 15-30℃, in hot and humid places.

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