CARDURA

Cardura is a brand name for a generic medication called Doxazosin. It is a prescription drug that got FDA approval in 1990 for the treatment of hypertension and symptoms of Benign Prostatic Hyperplasia (BPH) in men.

Cardura has Doxazosin mesylate as its active ingredient. Doxazosin mesylate belongs to a class of medications known as alpha-1 blockers. Its primary function is to block the activation of alpha-1 adrenergic receptors in the body. By doing so, doxazosin mesylate helps to relax and widen the blood vessels and certain muscles, particularly those in the prostate and bladder neck.

The main therapeutic uses of doxazosin mesylate in Cardura are for the treatment of Benign Prostatic Hyperplasia (BPH) and the management of Hypertension.

The following inactive ingredients in this medication are sodium starch glycolate, sodium lauryl sulfate, microcrystalline cellulose, and magnesium stearate. Doxazosin mesylate is a quinazoline compound, a selective inhibitor of alpha-1 adrenergic receptors. It is chemically designated as 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4benzodioxan-2-ylcarbonyl) piper zine methanesulfonate.

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Cardura belongs to the pharmacological class: Alpha-adrenoreceptor antagonists- the peripherally acting antiadrenergic agents.

• Alpha-adrenoreceptor antagonists are the peripherally acting blockers of the alpha-1 or alpha-2 adrenergic receptors, located at the nerve endings of the sympathetic nervous system. Alpha-1 is present on the vascular smooth muscles and Alpha-2 receptors are present on the sympathetic nerve terminals.
• Cardura medication acts only on the alpha-1 adrenergic receptor and helps relax the smooth muscles around the arteries and veins as well as the muscles in the neck of the urinary bladder and prostate gland. Thus, it can help reduce hypertension and improve urination in men with an enlarged prostate.

Cardura is available as:

• White tablet containing 1mg doxazosin as free base.
• Yellow tablet containing 2mg doxazosin as free base and D and C yellow 10; FD and C yellow 6.
• Orange tablet containing 4mg doxazosin as free base and FD and C yellow 6.
• Green tablet containing 8mg doxazosin as a free base along with FD and C blue 2 and D and C yellow 10.

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Cardura can treat the following medical conditions:

• Hypertension: It is high blood pressure. Blood pressure is the force that the blood exerts on the arterial walls while flowing through the arteries. Normally, the systolic and diastolic blood pressures are 120 and 80. With hypertension, the measured blood pressure is high indicating harder working of the heart. The signs of hypertension include chest pain, headache, blurred vision, difficulty bleeding, nose bleeds, and weakness or dizziness.    
• Benign Prostatic Hyperplasia (BPH): It is a benign enlargement of the prostate gland in men that may cause the urethra (urine tube) to compress and obstruct the urine flow from the urinary bladder through the urine tube to the outside. Prostate enlargements commonly occur in older adults because of either the increase in number of prostate cells (hyperplasia) or the increase in the size of the prostate cells (hypertrophy). The symptoms of BPH include frequent urination, a constant urge to urinate, troubled starting of urine flow or stopping it, weak urine stream or dribbling following urination, and a feeling of not completely emptying the urinary bladder when urinating.

• The suggested dose for adults having hypertension: Initially take 1mg once a day. To maintain the dose concentration in blood, titrate the dose as per requirement up to 16 mg once daily.
• The suggested dose for adults to treat Benign Prostatic Hyperplasia: Initially take 1mg once daily. Titrate the dose as per need after every 1-2 weeks, up to 8mg daily.
• The prescribed geriatric dose for hypertension: Initiate therapy at 0.5mg once a day.

Cardura comes in the form of colored tablets for oral administration. The tablets are designed to be swallowed whole and should not be chewed, crushed, or broken before consumption unless otherwise instructed by a healthcare professional.

Common side effects may include:

• Hypotension
• Dizziness
• Drowsiness
• Shortness of breath
• Runny nose
• Nausea
• Abdominal pain
• Diarrhea
• Edema(Swelling)
• Weight gain
• Weakness
• Tiredness
• Headache

Some serious, rarely-occurring side effects are:

• Allergic Reactions
• Light-Headedness
• Difficulty in Breathing.
• Fatigue
• Malaise
• Severe ongoing Stomach Ache or Bloating.
• Eye Problems during Cataract Surgery.
• New or Worsening Chest Pain.
• A Painful Penile Erection or Erection that lasts for 4 hours or longer (in men).

Some drugs known to interact with Cardura when taken together include:

• Antidepressants
• Antibiotics
• Medications to treat HIV/AIDS.
• Medications to treat Erectile Dysfunctions like Vardenafil and Sildenafil (Viagra).
• Strong Cytochrome P450 3A inhibitors
• Phosphodiesterase-5 inhibitors like tadalafil
• Alternative medications for hypertension include diuretics (water pills).

The intake of Cardura tablets is not safe for:

• Patients who have hypersensitivity to doxazosin, other quinazolines like terazosin and prazosin, or any other component in the formulation of the medication.
• Small children
• People who have low blood pressure, normal size of the prostate, severe constipation, a blockage in the digestive tract, or liver disease.
• Patients who have prostate cancer
• Patients who are undergoing cataract surgery.

• Avoid taking Cardura if allergic to Doxazosin or similar medications.
• Be careful while driving or doing anything that requires an alert mind. Avoid standing for long, suddenly changing positions, or getting your body overheated by doing exercises. Do take these precautions, until you are aware of what side effect Cardura has on your body.
• Avoid stopping Cardura intake without taking the doctor’s advice.
• Inform the doctor if you have planned cataract surgery or pregnancy. Also, tell the doctor if breastfeeding. 
• Tell the doctor beforehand about other medications you take or if you have any other illness.
• Avoid drinking alcohol while on Cardura medication therapy.

• Store Cardura tablets in their original packaging at controlled room temperature, preferably 25℃.
• Avoid keeping tablets in hot and humid places, at temperatures outside the range of 15-30℃.

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