CALAN

Calan is a brand name for a generic medication called Verapamil. It is a prescription medicine that has been approved by the FDA for various cardiovascular conditions. Verapamil belongs to a class of drugs known as calcium channel blockers.

Verapamil received FDA approval for the treatment of Hypertension(high blood pressure) in 1981. It works by relaxing and widening blood vessels, thereby improving blood flow and reducing blood pressure. Thereby aiding in managing hypertension (high blood pressure) and angina (chest pain) and addressing specific heart rhythm irregularities.

Verapamil Hydrochloride is the primary active compound found in Calan. It  is chemically designated as benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)hydrochloride.

Calan is classified as a calcium channel blocker and is prescribed for treating high blood pressure. Relaxing blood vessels facilitates improved blood flow, thus preventing strokes, heart attacks, and kidney issues. Additionally, Calan is also used to prevent chest pain. Furthermore, if one experiences a fast or irregular heartbeat like atrial fibrillation, Calan can regulate your heart rate effectively, promoting comfort and increasing exercise tolerance.

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Calan belongs to the therapeutic class of medication known as Calcium Channel Blockers (CCBs). Calcium channel blockers are a diverse class of drugs that work by obstructing the entry of calcium into the cells of the heart and blood vessels. This action helps relax and widen the blood vessels, reduces the workload on the heart, and enhances blood flow and oxygen supply to the heart muscle.

Here are some commonly available strengths of Calan tablets:

• 40 mg: This strength of Calan contains 40 milligrams of Verapamil. It is a lower dose option available.
• 80 mg: Calan tablets with a strength of 80 milligrams contain a slightly higher verapamil dose. It may be prescribed to individuals requiring a moderate dose of the medication.
• 120 mg: Calan with 120 milligrams contains a higher dose of verapamil. It may be prescribed for individuals with more severe conditions or who require a stronger therapeutic effect.
• 180 mg: These tablets contain 180 milligrams of Verapamil.
• 240 mg: Calan tablets with a strength of 240 milligrams provide the highest dose of Verapamil.

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The doctor prescribes Calan for various medical conditions, some of which include:

• Hypertension (High Blood Pressure): Calan is commonly recommended as a treatment for hypertension, aiding in reducing high blood pressure and its management.
• Angina: Calan can treat angina, a condition characterized by chest pain or discomfort due to reduced blood flow to the heart. By inducing the relaxation and dilation of blood vessels, Calan facilitates enhanced blood circulation to the cardiac muscles, alleviating angina symptoms and promoting better cardiovascular health.

In addition to its use in treating hypertension and angina, it is also prescribed for managing cardiac arrhythmias, and supraventricular tachycardia (SVT), and as a preventive measure for migraines.

For the treatment of Angina:

The typical recommended dose of Calan is between 80 mg and 120 mg, taken three times a day.

For the treatment of Arrhythmias:

The dosage for the treatment of Arrhythmias, the usual dosage ranges from 240 mg to 480 mg per day, divided into three or four equally spaced doses.

For the treatment of Hypertension:

The usual initial dose is 80 mg, taken three times a day, resulting in a total daily dose of 240 mg.

It is important to emphasize that these recommended dosage guidelines serve as a general reference and can vary based on unique factors such as age, weight, and medical history.

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Calan is administered through various routes, the most common being oral tablets. These tablets are taken by mouth and come in immediate-release and extended-release formulations. It should not be crushed, chewed, or broken. Instead, they should be swallowed whole. If you have difficulty swallowing it whole, it is recommended to consult your doctor or pharmacist.

If you notice any of the following Calan side effects, promptly consult your doctor:

• Chest pain, fast or slow heart rate
• A lightheaded feeling like you might pass out
• Shortness of breath
• Rapid weight gain
• Lung problems include anxiety, sweating, pale skin, wheezing, gasping for breath, and coughing with foamy mucus.
• Liver problems such as loss of appetite, upper stomach pain, tiredness, easy bruising or bleeding, dark urine, clay-colored stools, and Jaundice.

Common side effects of Calan may include:

• Headache
• Dizziness
• Constipation
• Flushing and low blood pressure
• Upper respiratory infection.

Some drugs that are known to interact with Calan tablets include:

• Aspirin
• Calcium supplements
• Morphine
• Antibiotics
• Aliskiren
• Clonidine
• Disopyramide
• Dofetilide
• Fingolimod
• Lithium

Before initiating Calan tablets, it is crucial to consider the following precautions:

• Calan should be avoided in patients with severe left ventricular dysfunction.
• Calan should be avoided in patients with acute myocardial infarction (heart attack) if they have pulmonary congestion, low blood pressure, or signs of heart failure.
• Calan should not be used in patients who have a known hypersensitivity or allergic reaction to verapamil or any of its components.
• Calan should not be used in children.

• While taking Calan, avoiding consuming large amounts of grapefruit or grapefruit juice is generally recommended.
• It is generally advised to avoid or limit alcohol consumption while taking Calan. Alcohol can interact with Verapamil and enhance its effects, potentially increasing drowsiness, dizziness, or light-headedness.
• It is advised to take herbal supplements while taking Calan as they may increase the risk of side effects or decrease effectiveness. St. John's wort, ginkgo biloba, and supplements that contain garlic must be avoided. Also, inform the doctor about other supplements one is taking while taking Calan.
• It is advisable to avoid consuming high-fat foods while taking Calan, as the medicine will be absorbed very slowly and less effectively when one is consuming high-fat meals. This will ensure ideal absorption and effectiveness.
• Avoid caffeine as it can increase heart rate and blood pressure, which may counteract the effects of Calan in managing these conditions.

• It is recommended to keep it in a tightly sealed container at room temperature. Ensure that it is stored away from heat, moisture, and direct light sources.
• Keep it out of reach of children and pets.

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