AZOPT (BRINZOLAMIDE)

Azopt is a brand name for a generic ophthalmic suspension called Brinzolamide. This prescription drug’s manufacturer is Alcon’s Laboratories. Azopt got FDA approval in 1998 for the treatment of certain types of glaucoma and to reduce elevated intraocular pressure in adult patients with ocular hypertension caused by other causes. It is available as a monotherapy in patients unresponsive to beta-blockers or those who cannot take beta blockers and even as a combination therapy with beta-blockers.

Azopt ophthalmic suspension contains Brinzolamide as its active ingredient, a preservative called benzalkonium chloride, a pH adjuster: hydrochloric acid and/or sodium hydroxide, and inactive ingredients including carbomer 974P, mannitol, purified water, edetate disodium, tyloxapol, and sodium chloride. Brinzolamide is a white, water-insoluble powder chemically designated as (R)(+)-4-Ethylamino-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno [3,2-e]-1,2-thiazine-6sulfonamide-1,1-dioxide.

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Azopt belongs to the pharmacological class of Ophthalmic glaucoma agents. It is a carbonic anhydrase inhibitor agent.

Ophthalmic glaucoma agents are the class of medications used to help reduce eye pressure in glaucoma patients who are at high risk of optic nerve damage because of increased ocular pressure. The medicine contains Brinzolamide and is used to treat elevated intraocular pressure in patients who are suffering from open-angle glaucoma.

This medicine works by decreasing the production of aqueous humor in the eyes and helps control intraocular pressure. Making it an effective option for the treatment of glaucoma, where intraocular pressure is increased and if left untreated it can cause vision loss.

Azopt ophthalmic suspension comes in a single strength: 1% (10mg/mL) brinzolamide. It is available in a plastic dispenser having a controlled dispensing tip: 10 mL and 15 mL.

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Azopt eye drops are given by doctors for the treatment of increased intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

Open-angle glaucoma is one of the types of glaucoma with no symptoms in the early stages; gradual development of patchy blind spots in the peripheral vision, and trouble seeing things in central vision in severe cases.

It is an eye disease that impairs vision because of optic nerve damage caused by fluid accumulation and increased pressure behind one or both eyes. The blockage caused by eye fluid deposits in the case of open-angle glaucoma is not diagnosable in the eye tests.

The suggested dose for Azopt ophthalmic suspension is one to two drops in the affected eye(s) three times every day. Before using the eye drop, the bottle must be shaken well and hands must be properly washed. The user must follow the instructions for use as given on the product label or by the eye doctor. In case more than one topical ophthalmic drug is in use, the administration of Azopt must be in at least 10-minute intervals.

Azopt is an ophthalmic suspension that the cornea of the eye absorbs following its topical administration into the eyes.

To apply Azopt: Slightly tilt your head back and bring down the lower eyelid to create a tiny pocket for the administration of eye drops.

Hold the dropper a little above the affected eye and squeeze it slightly to let a drop of solution fall into the created pocket. After administration, close your eyes for 1-2 minutes.

The common side effects may include:

• An Unusual, Bitter Mouth Taste.
• Blurred vision
• Dry eyes
• Eye itching
• Chest pain
• Chills
• Discharge from the eyes.
• Headache
• Nausea
• Dark urine

Serious side effects include:

• Allergic reaction.
• Severe skin reaction.
• Yellowing of the eyes or skin (a jaundice condition).
• Stomach ache in the upper right side.
• Pain in the eyes.
• Sensitivity of the eyes to light.
• Feeling of something in the eyes.
• Signs of an eye infection (Redness or Swelling of the eyes, Severe eye discomfort.)

Some of the drugs known to interact with Azopt include:

• Salicylates such as Aspirin.
• Salflex
• Doan’s Extra Strength.
• Novasal
• Tricosal
• Aspirin
• Citric acid
• Balsalazide
• Diflunisal
• Lisdexamfetamine.

Azopt ophthalmic suspension is not meant for use by:

• Anyone with known hypersensitivity to active ingredients, sulphonamide/sulfa drugs, or any other ingredients of Azopt.
• People with severe renal impairment may face issues to eliminate the drug from their body. This often causes accumulation of the medication and can cause severe adverse effects. So, in such issues it must not be given to patient with severe renal impairment.
• It must be avoided in people who are suffering from medical history of acidosis.
• People suffering from hyperchloremic acidosis.
• Individuals who ever had narrow-angle glaucoma.
• Breastfeeding mothers.
• Small children.

If using Azopt eye drops, it is important to take the following precautions:

• Do not wear contact lenses while administering Azopt ophthalmic suspension. Use Azopt at least 15 minutes before wearing lenses.
• Avoid driving or any hazardous activity as the eye drop may cause blurred vision and may hinder your reactions.
• Do not use any other eye medication without informing or taking advice from an eye doctor.
• Avoid using a contaminated tip of the Azopt eye drop dispenser.
• Avoid doubling or missing Azopt doses.
• Talk to a doctor about the safety of medication use at the time of pregnancy.

• Store the Azopt ophthalmic suspension bottle at 4 to 30 degrees Celsius and use it until its date of expiry.
• When not in use, keep the bottle tightly closed.
• Avoid keeping the eye drop bottle in damp areas like the bathroom.

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