ADCIRCA (TADALAFIL)

Adcirca is a brand name for a prescription generic drug called tadalafil. It got FDA approval in 2009 for the treatment of Pulmonary Arterial Hypertension. This medication helps relax the muscles of the blood vessels and improve blood circulation to particular body parts, thereby revamping exercise capacity in men and women.

Adcirca tablets contain tadalafil as its active ingredient and the following inactive ingredients: magnesium stearate, croscarmellose sodium, talc, hydroxypropyl cellulose, hypromellose, iron oxide, titanium dioxide, lactose monohydrate, triacetin, microcrystalline cellulose, and sodium lauryl sulfate. Tadalafil is a phosphodiesterase 5 inhibitor, a specific inhibitor of cyclic guanosine monophosphate. It is a crystalline solid with chemical name pyrazino[1’,2’:1,6]pyrido[3,4.b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)2,3,6,7,12,12a-hexahydro-2-methyl-, (6R,12aR)-.

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Adcirca is a phosphodiesterase-5 (PDE5) inhibitor that is categorized as an Agent for pulmonary hypertension. It is used to treat pulmonary arterial hypertension. Adcirca also improves the exercise capacity in both men and women.

The medicine functions by relaxing the muscles of blood vessels and it increases the blood flow in certain parts of the body.

Heart and lungs function better and the ability to exercise improves as Adcirca decreases the high blood pressure in the lungs.

Adcirca is available in 20 mg orange, film-coated, almond-shaped tablets imprinted with “4467”.It is a commonly available form of Adcirca available.

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Pulmonary Arterial Hypertension (PAH) is a condition characterized by high blood pressure in the arteries that supply the lungs. Adcirca is used in the treatment of PAH (WHO Group1) to improve exercise abilities in men and women. The medicine relaxes and widens the blood vessels which improves the blood flow in the lungs and helps reduce work flow on the heart. This also helps improve exercise capacity and help manage symptoms and improve quality of life.

This medicine is also marketed under the brand name Cialis and is also used to treat erectile dysfunction (ED). But, the dosages of the medicine for these two conditions may differ.

For the treatment of Pulmonary Hypertension:

The usual adult dose is 40 mg (two 20 mg tablets) once daily. However, dosage adjustments could be made based on individual response and tolerability.

In the case of Adcirca tablets, the route of administration is oral. It is to be taken by mouth. It can usually be administered orally in the form of tablets. It is usually recommended to be swallowed with water, and prescribing healthcare professionals provide the specific dosages and timing instructions. Adcirca can be taken with or without food usually and the recommended dosage of two Adcirca of 20 mg for a full dose. Do not take more than prescribed by the doctor.

If you notice the following side effects it is recommended to consult with your doctor immediately:

• Chest pain or pressure.
• Pain spreading in the jaw or shoulder.
• Muscle pain
• Pain in the back, legs, arms.
• Flushing
• Stomach upset.
• A runny nose may occur.

Severe side effects:

• Hives
• Pain in the chest area
• Breathing heavily
• Change in the vision
• Sweating
• Pain in eyes
• Slurred speech
• Loss of coordination
• High fever
• Tremors
• Nausea
• Sudden vision loss.
• Sudden hearing loss or buzzing in your ears.
• Erection is painful or lasts longer than 4 hours.

Some of the drugs, products, and pills that are known to interact with Adcirca include:

• Albuterol
• Allopurinol
• Amlodipine
• Aspirin
• Atorvastatin
• Cymbalta (duloxetine)
• Eliquis (apixaban)
• Famotidine
• Furosemide
• Gabapentin
• Furosemide
• Letairis (ambrisentan)
• Levothyroxine
• Lisinopril
• Metformin
• Omeprazole

Before initiating Adcirca or while on Adcirca medication, there are a few precautions that need to be considered which include:

• Adcirca must not be taken with nitrates, as this can cause significant decrease in blood pressure.
• In case of liver disease or kidney diseases consult the doctor before the intake of Adcirca.
• If one is having an allergic reaction to tadalafil and other related agents present in this medicine they must avoid this medication.
• People with heart conditions, like those who have encountered heart attack, or severe heart failure, may be at bigger risk of complications and must take Adcirca with caution.
• Consult the doctor before taking Adcirca if there is a stomach ulcer.

• Avoid drinking alcohol as it increases the risk of dizziness or fainting.
• Avoid grapefruit as it can interact with Adcirca and may lead to unwanted side effects.
• This medicine must not be taken with organic nitrates or nitric oxide donors, as this can drop the patient's blood pressure.
• Adcirca should be avoided in the case of retinitis pigmentosa which is an inherited condition of the eye.
• In case of hearing problems or in case of blindness in one or both eyes it should be avoided.
• Adcirca should be avoided in case of heart problems such as chest pain, and heart failure.
• If one is pregnant, planning to become pregnant, or breastfeeding, one must take this medicine only after consulting the doctor.

To ensure proper storage of Adcirca tablets, follow these guidelines:

• Keep it at a controlled room temperature between 20-25 degrees Celsius.
• Keep it away from excessive heat and direct sunlight.
• Keep it out of reach of children or pets.

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