ADALAT XL (NIFEDIPINE)

Adalat XL is a brand name for a generic medication called nifedipine. It is a prescription extended-release tablet used for the management of mild to moderate essential hypertension (high blood pressure) and effort-associated angina (chronic stable angina) without evidence of vasospasm in patients who still show symptoms even after intake of adequate doses of beta blockers and/or nitrates or who cannot tolerate these antianginal agents. Normally, Adalat XL is given to hypertensive patients who did not respond to treatment with diuretics or beta-blockers or have suffered from unacceptable serious effects of taking it.

Adalat XL tablets contain Nifedipine as its active ingredient. Nifedipine is a fine, yellowish, light-sensitive powder that is practically insoluble in water but soluble in ethanol. It is chemically designated as 1,4-dihydro-2, 6-dimethyl-4-(o-nitrophenyl)-3,5- pyridine dicarboxylic acid dimethyl. It contains other substances like cellulose acetate, ferric oxide (E 172), hydroxypropyl cellulose, sodium chloride, propylene glycol, titanium oxide, etc.

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Adalat XL is categorized in the class of Calcium Channel Blockers and dihydropyridine. It is used to treat chronic chest pain and mild to moderate hypertension (high blood pressure).

It is normally used in patients whose treatment with diuretics or beta-blockers has been ineffective or is associated with severe adverse effects. It also helps in the treatment of mild to moderate essential hypertension (high blood pressure).

Adalat XL is available in the following strengths:

• Adalat XL 20 mg tablet. (Round, convex, pink, coated tablet with laser on one side and marked in black printed text of ADALAT 20 on one side).
• Adalat XL 30 mg tablet. (Round, convex, pink, coated tablet with laser on one side and marked in black printed text of ADALAT 30 on one side).
• Adalat XL 60 mg tablet. (Round, convex, pink, coated tablet with laser on one side and marked in black printed text of ADALAT 40 on one side).

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• Chronic Stable Angina (effort-associated angina): Adalat XL is employed in the treatment of chronic chest pain or chronic stable angina. This medical condition causes chest discomfort or pain that is triggered by physical exertion or emotional stress. The medicine Adalat XL relaxes and dilates the blood vessels of the coronary arteries that supply blood to the heart muscle. This causes a vasodilatory effect, improves the flow of blood, reduces the workload on the heart, and helps manage the symptoms of angina.
• Hypotension (Low Blood Pressure): This medicine is a calcium channel blocker that also helps to lower mild to moderate hypertension.

• For the treatment of Hypertension: The usual dose normally should be initiated with 20 mg or 30 mg once daily. The maintenance dose is 30 mg to 60 mg once daily. Note: Doses more than 90 mg daily should be avoided.
• For the treatment of Chronic stable Angina: The medicine should be initiated with 30 mg once daily and doses greater than 90 mg in patients with angina are limited.

In the case of Adalat XL tablets, the route of administration is oral. It is to be taken by mouth. It can usually be administered orally in the form of tablets. It is usually recommended to be swallowed with water, and the specific dosages and timing instructions are provided by a doctor. Adalat XL should be taken at approximately 24-hour periods i.e. same time every day but preferred during the morning. Adalat XL need not be taken with meals. Do not take more than prescribed by the doctor.

Common Side Effects:

• Dry mouth
• Indigestion
• Leg cramps
• The feeling of being unwell
• Flushing
• Constipation
• Swelling, particularly in the ankle or leg.

Severe side effects:

• Difficulty in breathing.
• Swelling which includes potential life-threatening swelling of the face, lips, tongue, and throat.
• Mucosal reaction in the mouth or nose.
• Severe headache
• Serious eye symptoms which include sudden vision loss, blurred vision, or hailing around lights.
• Symptoms of liver problems include diarrhea, loss of appetite, weight loss, yellowing of skin as well and dark urine.
• Severe skin reactions like blistering, peeling, and a rash that covers large areas of the body.

Some of the drugs, products, and pills that are known to interact with Adalat XL include:

• Benzodiazepines
• Cisapride
• Tacrolimus
• Imipramine propafenone
• Terfenadine
• Warfarin
• HIV protease inhibitors
• Nefazodone
• Quinidine
• Rifampicin
• Phenytoin

Iressa is not safe for intake by:

• Adalat XL should be used cautiously in patients with angina who are known to develop hypotension as Adalat XL lowers peripheral vascular resistance and blood pressure.
• In case of heart disease or heart failure, Adalat XL should be used very cautiously.
• If one is allergic to nifedipine or any other components of the medicine, then they should not take this medication.
• If one has a history of heart problems, liver disease, or low blood pressure they may not be a suitable candidate for taking this medicine.
• Adalat XL should not be used in case of pregnancy or proper consultation with the doctor is a must in such cases.

• While using Adalat XL, there are no specific dietary restrictions or precautions. It is always a good idea to follow a balanced and healthy diet.
• But to ensure the safe and effective use of Adalat XL, it is advised to consider the following precautions.
• Avoid grapefruit as it can interact with Adalat XL and may lead to increased levels of nifedipine in blood which can lead to potential side effects.
• Avoid drinking alcohol as it increases the risk of dizziness or fainting.
• Medicine that can inhibit CYP3A4 enzyme in the liver must be avoided while taking this medicine can they can interact with this medicine.
• Do not take other antihypertensive drugs while taking this medicine.
• Pregnant and breastfeeding women must take this medicine only after consulting a doctor.

To ensure proper storage of Adalat XL tablets, follow these guidelines:

• Keep it at a controlled room temperature between 20-25 degrees Celsius.
• Keep it away from excessive heat and direct sunlight.
• Keep it out of reach of children or pets.

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