ACCURETIC (QUINAPRIL HYDROCHLORIDE/HYDROCHLOROTHIAZIDE)

Accuretic is a brand name for a combination generic drug called Quinaretic, having Quinapril Hydrochloride and Hydrochlorothiazide. This medicine got FDA approval in 1999 for use in treating severe hypertension (high blood pressure) in adults, thereby lowering their risk of heart attack or stroke. Its manufacturer is Pfizer Inc., a biopharmaceutical company headquartered in New York, United States.

Accuretic tablet contains two active ingredients: Quinapril Hydrochloride and Hydrochlorothiazide and the following inactive ingredients: polyethylene glycol, candelilla wax, hydroxypropyl cellulose, hypromellose, crospovidone, iron oxide red/yellow, lactose, magnesium stearate, magnesium carbonate, povidone, and titanium dioxide. Quinapril Hydrochloride is chemically designated as [3S-[2[R*(R*)], 3R*]]-2-[2-[[1(ethoxycarbonyl)-3-phenylpropyl] amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3isoquinolinecarboxylic acid, monohydrochloride and Hydrochlorothiazide has chemical name 6-Chloro-3,4-dihydro-2H-1,2,4benzothiadiazine-7-sulfonamide 1,1-dioxide.

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Accuretic belongs to the pharmacological class: ACE inhibitors with thiazide. It is a fixed combination medication containing an angiotensin-converting enzyme (ACE) inhibitor- quinapril hydrochloride, and a diuretic/thiazide- hydrochlorothiazide.

An ACE inhibitor blocks the activity of the angiotensin enzyme, which means the conversion of angiotensin I to angiotensin II. This conversion leads to high levels of angiotensin II which constricts arteries and veins and causes increased blood pressure. The inhibition of the enzyme leads to a reduction in angiotensin II which causes vasodilation and therefore reduced blood pressure.

A diuretic increases the excretion of potassium, sodium, and chloride through urine, thus reducing the extra blood pressure. As ACE inhibitors and diuretics ultimately help reduce blood pressure, both when used in combination can lead to a significant reduction in very high blood pressure.

Accuretic tablets come in three strengths:

• 10/12.5: This strength tablet is film-coated, pink, biconvex, and elliptical with the “PD 222” code on one side and both sides scoring. It contains 10 mg of quinapril hydrochloride and 12.5 mg of hydrochlorothiazide.
• 20/12.5: This strength tablet is film-coated, pink, biconvex, and triangular with “PD 220” code on one side and one side scoring. It contains 20 mg of quinapril hydrochloride and 12.5 mg of hydrochlorothiazide.
• 20/25: This strength tablet is film-coated, pink, biconvex, and round with “PD 223” coded on one side and one side scoring. It contains 20 mg of quinapril hydrochloride and 25 mg of hydrochlorothiazide.

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Accuretic is given by doctors to reduce blood pressure in severely hypertensive patients. Hypertension, commonly called as high blood pressure, is a condition wherein an individual has repeatedly elevated systolic blood pressure over 140mmHg or a diastolic blood pressure above 90mmHg.

It is more common in older adults. The symptoms of extremely elevated blood pressure include fatigue, severe headaches, chest pain, vision issues, blood in the urine, irregular heartbeat, troubled breathing, and pounding in the neck, chest, or ears.

If an Accuretic is not taken to treat severe hypertension, persistent increased blood pressure can cause serious health complications. It can damage the blood vessels in the eye retina, cause unusual thickening of the cardiac muscles, and even lead to kidney failure and brain damage.

For patients who have not been taking any diuretic currently, the suggested initial dosage of Accuretic is one 10/12.5mg tablet once daily with or without food. The dosage of Accuretic can be increased to one 20/12.5mg tablet once daily and thereafter to two 10/12.5mg tablets once daily, in case of inadequate reduction of blood pressure. The recommended dosage of Accuretic can range from 10 to 80 mg of quinapril and 12.5 to 50 mg of hydrochlorothiazide once daily.

Accuretics are available in the form of tablets meant only for oral administration. Take the medication as per the doctor’s instructions and the directions given on the prescription label. It's important to follow the prescribed dosage and frequency to safeguard optimal effectiveness and minimize the risk of side effects. If you have any concerns about how to take Accuretics, consult your doctor for clarification.

Commonly reported side effects of taking Accuretic include:

• Headache
• Tiredness
• Dizziness
• Muscle pain or Backache.
• Cough
• Diarrhea, constipation, or upset stomach.

Accuretic rarely cause serious side effects including:

• Signs of infection such as fever, chills, and persistent sore throat.
• Muscle pain or joint aches.
• Vision problems.
• Easy skin bruising and bleeding.
• Swelling, tingling, and numbness of the feet or hands.
• Signs of hypotension.
• A serious allergic reaction.

Some of the drugs and supplements that are known to interact with Accuretic include:

• Potassium supplements.
• Cold or allergy medicine.
• Narcotic painkillers.
• Sedatives
• Muscle relaxers.
• Other diuretics (water pills).
• Lithium-based drugs.
• Other medications to treat blood pressure.
• Gold injections.
• Antibiotics
• Colestipol
• Steroids or NSAIDs.
• Oral diabetes medicine or Insulin.

Accuretic tablet is not meant to be taken or is unsafe for use by:

• Anyone having known hypersensitivity to any of the components of Accuretic tablets or other sulfonamide-derived drugs.
• Patients with anuria.
• People who suffer from hypotension.
• Patients who have a history of hereditary and/or idiopathic angioedema or angioedema related to earlier treatment with ACE inhibitors.
• Patients suffering from kidney disease, congestive heart failure, glaucoma, cirrhosis or other live disease, gout, or lupus.
• People who are on a low sodium diet.
• Diabetic individuals and patients with hyperkalemia, moderate or severe kidney insufficiency, and congestive heart failure who have been taking Aliskiren.
• Pregnant women or women who tend to get pregnant.
• Breastfeeding mothers.
• Anyone younger than 18 years old.

Before starting the treatment course with Accuretic, the doctor recommends the patient follow these precautions:

• Avoid direct sunlight exposure or use of tanning beds and sun-protect the skin with sunblock and sun-protective clothes as hydrochlorothiazide in Accuretic may increase the risk of skin cancer.
• Avoid alcohol intake as it may interfere with accuretics and further lower blood pressure.
• Avoid changing positions swiftly as accuretics may cause dizziness.
• Avoid getting your body overheated or dehydrated.
• If pregnant or planning to conceive a child or if breastfeeding, inform the doctor beforehand.
• Inform the doctor beforehand about the current intake of medications and supplements and if having any illnesses or allergies.
• Do not change the dosage or stop the intake of Accuretic without first consulting the doctor. Avoid doubling or missing doses.

• In tight containers, store Accuretic tablets at controlled room temperature, preferably at 20 to 25°C.
• Do not expose the tablets to extreme temperatures or direct sunlight.
• Keep it away from the reach of children and pets.

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